PMID- 11748662
OWN - NLM
STAT- MEDLINE
DCOM- 20020205
LR  - 20190901
IS  - 0146-6615 (Print)
IS  - 0146-6615 (Linking)
VI  - 66
IP  - 1
DP  - 2002 Jan
TI  - Fatal adult case of severe lymphocytopenia associated with reactivation of human 
      herpesvirus 6.
PG  - 82-5
AB  - It has been suggested that immunosuppression associated with human herpesvirus 6 
      (HHV-6) infection is a result of functional impairment or direct destruction of 
      immunological cells. The ability of the virus to infect and destroy lymphocytes 
      may cause progressive immunodeficiency in an infant with primary HHV-6 infection. 
      An adult patient is described who had a fatal cytomegalovirus (CMV) infection due 
      to severe and prolonged lymphocyte depletion associated with HHV-6 reactivation. 
      The HHV-6 antibody titers were increased significantly after reactivation, and 
      the virus was isolated from his peripheral blood mononuclear cells. The quantity 
      of both HHV-6 and CMV DNA was determined by using real-time PCR in plasma samples 
      collected serially. HHV-6 DNAemia persisted for 1 month, which started just 1 
      week after the onset of lymphocytopenia. In contrast to HHV-6, CMV DNAemia was 
      detected in the terminal phase of the illness. Thus, HHV-6 reactivation may have 
      been the cause of the severe lymphocyte depletion and fatal CMV infection.
CI  - Copyright 2002 Wiley-Liss, Inc.
FAU - Yoshikawa, Tetsushi
AU  - Yoshikawa T
AD  - Laboratory of Virology, Research Institute for Disease Mechanism and Control, 
      Nagoya University School of Medicine, Nagoya, Japan. tetsushi@med.nagoya-u.ac.jps
FAU - Ihira, Masaru
AU  - Ihira M
FAU - Asano, Yoshizo
AU  - Asano Y
FAU - Tomitaka, Akiko
AU  - Tomitaka A
FAU - Suzuki, Kayoko
AU  - Suzuki K
FAU - Matsunaga, Kayoko
AU  - Matsunaga K
FAU - Kato, Yasuchika
AU  - Kato Y
FAU - Hiramitsu, Sinya
AU  - Hiramitsu S
FAU - Nagai, Tomohito
AU  - Nagai T
FAU - Tanaka, Naoko
AU  - Tanaka N
FAU - Kimura, Hiroshi
AU  - Kimura H
FAU - Nishiyama, Yukihiro
AU  - Nishiyama Y
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
SB  - IM
MH  - Aged
MH  - Cytomegalovirus/genetics/isolation & purification
MH  - Cytomegalovirus Infections/*etiology
MH  - Fatal Outcome
MH  - Herpesvirus 6, Human/genetics/*growth & development/isolation & purification
MH  - Humans
MH  - Lymphopenia/*etiology
MH  - Male
MH  - Roseolovirus Infections/*complications
MH  - *Virus Activation
EDAT- 2001/12/19 10:00
MHDA- 2002/02/06 10:01
CRDT- 2001/12/19 10:00
PHST- 2001/12/19 10:00 [pubmed]
PHST- 2002/02/06 10:01 [medline]
PHST- 2001/12/19 10:00 [entrez]
AID - 10.1002/jmv.2114 [pii]
AID - 10.1002/jmv.2114 [doi]
PST - ppublish
SO  - J Med Virol. 2002 Jan;66(1):82-5. doi: 10.1002/jmv.2114.