PMID- 11748915
OWN - NLM
STAT- MEDLINE
DCOM- 20020319
LR  - 20171116
IS  - 1065-6995 (Print)
IS  - 1065-6995 (Linking)
VI  - 25
IP  - 12
DP  - 2001
TI  - Ultraviolet B irradiation modulates susceptibility to tumour necrosis 
      factor-alpha-induced apoptosis via induction of death receptors in murine 
      fibroblasts.
PG  - 1221-8
AB  - Ultraviolet B (UVB) irradiation causes cell death by apoptosis in murine 
      fibroblast cells. Tumor necrosis factor-alpha (TNF-alpha) is also a well known 
      inducer of apoptosis, although the physiological significance of this activity is 
      poorly understood. We investigated the effects of pretreatment with UVB (312 nm) 
      on TNF-alpha-induced apoptosis in murine fibroblast cells. UVB enhanced 
      susceptibility to cell death by TNF-alpha in a dose-dependent manner. UVB but not 
      TNF-alpha induced the expression of TNF receptor type-1 (TNFR-1) and type-2 
      (TNFR-2) in a dose-dependent manner. Expression of Fas (CD95) and Fas-ligand 
      (Fas-L), and significant DNA fragmentation were observed in the cells that died. 
      These results suggest that UVB irradiation modulates susceptibility to 
      TNF-alpha-induced apoptosis through the induction of TNFRs, Fas, and Fas-L in 
      murine fibroblasts.
CI  - Copyright 2001 Academic Press.
FAU - Kimura, H
AU  - Kimura H
AD  - Department of Biological Sciences, Faculty of Engineering, Gunma University, 
      Kiryu, Gunma 376-8515, Japan.
FAU - Minakami, H
AU  - Minakami H
FAU - Shoji, A
AU  - Shoji A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Cell Biol Int
JT  - Cell biology international
JID - 9307129
RN  - 0 (Antigens, CD)
RN  - 0 (Fas Ligand Protein)
RN  - 0 (Fasl protein, mouse)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (fas Receptor)
SB  - IM
MH  - Animals
MH  - Antigens, CD/*metabolism
MH  - Apoptosis/*drug effects
MH  - Cell Survival/drug effects/radiation effects
MH  - Cells, Cultured/drug effects/radiation effects
MH  - DNA Fragmentation
MH  - Dose-Response Relationship, Drug
MH  - Dose-Response Relationship, Radiation
MH  - Fas Ligand Protein
MH  - Fibroblasts/*drug effects/metabolism/*radiation effects
MH  - Membrane Glycoproteins/metabolism
MH  - Mice
MH  - Receptors, Tumor Necrosis Factor/*metabolism
MH  - Receptors, Tumor Necrosis Factor, Type I
MH  - Receptors, Tumor Necrosis Factor, Type II
MH  - Tumor Necrosis Factor-alpha/*pharmacology
MH  - Ultraviolet Rays
MH  - fas Receptor/metabolism
EDAT- 2001/12/26 10:00
MHDA- 2002/03/20 10:01
CRDT- 2001/12/26 10:00
PHST- 2001/12/26 10:00 [pubmed]
PHST- 2002/03/20 10:01 [medline]
PHST- 2001/12/26 10:00 [entrez]
AID - S1065-6995(01)90805-4 [pii]
AID - 10.1006/cbir.2001.0805 [doi]
PST - ppublish
SO  - Cell Biol Int. 2001;25(12):1221-8. doi: 10.1006/cbir.2001.0805.