PMID- 11750987 OWN - NLM STAT- MEDLINE DCOM- 20020401 LR - 20211203 IS - 0304-3940 (Print) IS - 0304-3940 (Linking) VI - 317 IP - 1 DP - 2002 Jan 4 TI - Brain-derived neurotrophic factor alters cell migration of particular progenitors in the developing mouse cerebral cortex. PG - 21-4 AB - Effects of brain-derived neurotrophic factor (BDNF) on cell migration from the ventricular zone to the cortical plate (CP) in developing mouse cerebral cortex were examined. BDNF (700 ng) was injected into the brain ventricle of 13- or 14-day-old embryos (E13 or E14) after the intraperitoneal administration of 5-bromodeoxyuridine (BrdU) to pregnant mice. BDNF injection at E13 increased the number of BrdU-positive cells migrated into the CP until E15, and caused them to become localized in much deeper layers (V-VI) than expected (IV-V, as in the vehicle-treated mice) by postnatal day 1. However, when the injections were made at E14, BrdU-positive cells predominantly migrated to layers II/III irrespective of BDNF administration. These results demonstrate that BDNF affects particular progenitors at limited stages, and suggest the presence of a Reelin-independent mechanism(s) to regulate cell migration. FAU - Ohmiya, Makoto AU - Ohmiya M AD - Laboratory of Molecular Biology, Gifu Pharmaceutical University, Mitahora-higashi 5-6-1, Gifu 502-8585, Japan. FAU - Shudai, Toshihiro AU - Shudai T FAU - Nitta, Atsumi AU - Nitta A FAU - Nomoto, Hiroshi AU - Nomoto H FAU - Furukawa, Yoshiko AU - Furukawa Y FAU - Furukawa, Shoei AU - Furukawa S LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Ireland TA - Neurosci Lett JT - Neuroscience letters JID - 7600130 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Reelin Protein) RN - EC 3.4.21.- (Reln protein, mouse) RN - G34N38R2N1 (Bromodeoxyuridine) SB - IM MH - Animals MH - Body Patterning/drug effects/*physiology MH - Brain-Derived Neurotrophic Factor/*metabolism/pharmacology MH - Bromodeoxyuridine MH - Cell Differentiation/drug effects/*physiology MH - Cell Division/drug effects/physiology MH - Cell Movement/drug effects/*physiology MH - Cerebral Cortex/cytology/drug effects/*embryology MH - Female MH - Fetus MH - Gene Expression Regulation, Developmental/drug effects/physiology MH - Injections, Intraventricular MH - Mice MH - Mice, Inbred Strains MH - Neurons/cytology/drug effects/*metabolism MH - Pregnancy MH - Reelin Protein MH - Stem Cells/cytology/drug effects/*metabolism EDAT- 2001/12/26 10:00 MHDA- 2002/04/02 10:01 CRDT- 2001/12/26 10:00 PHST- 2001/12/26 10:00 [pubmed] PHST- 2002/04/02 10:01 [medline] PHST- 2001/12/26 10:00 [entrez] AID - S0304394001024120 [pii] AID - 10.1016/s0304-3940(01)02412-0 [doi] PST - ppublish SO - Neurosci Lett. 2002 Jan 4;317(1):21-4. doi: 10.1016/s0304-3940(01)02412-0.