PMID- 11751035
OWN - NLM
STAT- MEDLINE
DCOM- 20020305
LR  - 20150311
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 26
IP  - 1
DP  - 2002 Jan
TI  - Dual effect of central injection of recombinant rat interleukin-4 on 
      lipopolysaccharide-induced sickness behavior in rats.
PG  - 86-93
AB  - Systemic administration of the bacterial endotoxin lipopolysaccharide (LPS) has 
      profound depressive effects on behavior that are mediated by the inducible 
      expression of pro-inflammatory cytokines, such as interleukin-1 (IL-1), IL-6 and 
      tumor necrosis factor alpha (TNF), in the brain. To assess the regulatory effects 
      of the anti-inflammatory cytokine IL-4 on LPS-induced sickness behavior, rats 
      injected intra-peritoneally (i.p.) with LPS were administered 
      intracerebroventricularly (i.c.v.) with IL-4. IL-4 (30 and 300 ng) potentiated 
      the behavioral effects of LPS (175 microg/1000 g) when both molecules were 
      co-injected. However, when IL-4 (30 ng) was injected 12 h prior to LPS, it 
      blocked the depressing effects of LPS on social exploration. These results 
      indicate that the regulation of cytokine-induced sickness behavior by IL-4 can be 
      either inhibitory or stimulatory depending on the sequencing of IL-4 and LPS 
      treatments.
FAU - Bluthe, Rose Marie
AU  - Bluthe RM
AD  - Integrative Neurobiology Laboratory, INRA-INSERM U394, Institut Francois 
      Magendie, Rue Camille Saint-Saens, 33077, Bordeaux cedex, France. 
      rose-marie.bluthe@bordeaux.inserm.fr
FAU - Lestage, Jacques
AU  - Lestage J
FAU - Rees, Gwen
AU  - Rees G
FAU - Bristow, Adrian
AU  - Bristow A
FAU - Dantzer, Robert
AU  - Dantzer R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Recombinant Proteins)
RN  - 207137-56-2 (Interleukin-4)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Exploratory Behavior/drug effects
MH  - Injections, Intraperitoneal
MH  - Injections, Intraventricular
MH  - Interleukin-4/administration & dosage/*pharmacology/*toxicity
MH  - Lipopolysaccharides/administration & dosage/*antagonists & inhibitors/*toxicity
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Recombinant Proteins/administration & dosage/pharmacology
MH  - Social Behavior
MH  - Time Factors
EDAT- 2001/12/26 10:00
MHDA- 2002/03/07 10:01
CRDT- 2001/12/26 10:00
PHST- 2001/12/26 10:00 [pubmed]
PHST- 2002/03/07 10:01 [medline]
PHST- 2001/12/26 10:00 [entrez]
AID - S0893133X01003050 [pii]
AID - 10.1016/S0893-133X(01)00305-0 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 2002 Jan;26(1):86-93. doi: 
      10.1016/S0893-133X(01)00305-0.