PMID- 11755138
OWN - NLM
STAT- MEDLINE
DCOM- 20020725
LR  - 20191210
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 433
IP  - 1
DP  - 2001 Dec 14
TI  - Increased anxiety and impaired memory in rats 3 months after administration of 
      3,4-methylenedioxymethamphetamine ("ecstasy").
PG  - 91-9
AB  - Male Wistar rats were administered either (a) a high dose regime of 
      3,4-methylenedioxymethamphetamine (MDMA) (4 x 5 mg/kg, i.p. over 4 h on each of 2 
      consecutive days), (b) a moderate dose regime of MDMA (1 x 5 mg/kg on each of 2 
      consecutive days), (c) D-amphetamine (4 x 1 mg/kg over 4 h on each of 2 days), or 
      (d) vehicle injections. The high MDMA dose regime and the amphetamine treatment 
      both produced acute hyperactivity and hyperthermia. Twelve weeks later, all rats 
      were tested in the drug-free state on a battery of anxiety tests (elevated plus 
      maze, emergence and social interaction tests). A further 2 weeks later they were 
      tested on a novel object recognition memory task. Rats previously given the 
      neurotoxic dose of MDMA showed greater anxiety-like behaviour on all three 
      anxiety tests relative to both controls and D-amphetamine-treated rats. Rats 
      given the moderate MDMA dose regime also showed increased anxiety-like behaviour 
      on all three tests, although to a lesser extent than rats in the high dose group. 
      In the object recognition task, rats given the high MDMA dose regime showed 
      impaired memory relative to all other groups when tested at a 15-min delay but 
      not at a 60-min delay. Rats previously exposed to amphetamine did not differ from 
      saline controls in the anxiety or memory tests. These data suggest that moderate 
      to heavy MDMA exposure over 48 h may lead to increased anxiety and memory 
      impairment 3 months later, possibly through a neurotoxic effect on brain 
      serotonin systems.
FAU - Morley, K C
AU  - Morley KC
AD  - Department of Psychology, University of Sydney, Sydney, NSW 2006, Australia.
FAU - Gallate, J E
AU  - Gallate JE
FAU - Hunt, G E
AU  - Hunt GE
FAU - Mallet, P E
AU  - Mallet PE
FAU - McGregor, I S
AU  - McGregor IS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Illicit Drugs)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Anxiety/*chemically induced
MH  - Body Temperature/drug effects
MH  - Illicit Drugs/*toxicity
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory Disorders/*chemically induced
MH  - Motor Activity/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Rats
MH  - Rats, Wistar
MH  - Social Behavior
EDAT- 2002/01/05 10:00
MHDA- 2002/07/26 10:01
CRDT- 2002/01/05 10:00
PHST- 2002/01/05 10:00 [pubmed]
PHST- 2002/07/26 10:01 [medline]
PHST- 2002/01/05 10:00 [entrez]
AID - S0014-2999(01)01512-6 [pii]
AID - 10.1016/s0014-2999(01)01512-6 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2001 Dec 14;433(1):91-9. doi: 10.1016/s0014-2999(01)01512-6.