PMID- 11755926
OWN - NLM
STAT- MEDLINE
DCOM- 20020405
LR  - 20190718
IS  - 0021-9150 (Print)
IS  - 0021-9150 (Linking)
VI  - 160
IP  - 1
DP  - 2002 Jan
TI  - The role of chemokines in human cardiovascular pathology: enhanced biological 
      insights.
PG  - 91-102
AB  - A growing body of experimental evidence supports the pivotal role of chemokines 
      in the pathogenesis of vascular disease. The endothelial expression of monocyte 
      chemoattractant protein-1 (MCP-1) is apparently essential for the earliest 
      cellular responses of atherogenesis. Many atherogenic and anti-atherogenic 
      stimuli can be construed to exert their effects predominantly upon MCP-1 
      expression within the vascular wall. The atherogenic effects of interleukin-8 
      (IL-8) seem to be mediated through the down-regulation of the tissue inhibitor of 
      metalloproteinase-1 (TIMP-1). Biological expression of these two important 
      vascular chemokines is further modulated by NF-kappaB. The delineation of these 
      molecular forces that drive atherogenesis increasingly underscores the pivotal 
      role of various chemokines. It is anticipated that more precise delineation of 
      these patterns of gene expression will help to identify molecular targets for the 
      prevention and treatment of atherosclerosis.
FAU - Shin, William S
AU  - Shin WS
AD  - Division of Cardiovascular Medicine, Stanford University School of Medicine, 
      Stanford, CA 94306, USA.
FAU - Szuba, Andrzej
AU  - Szuba A
FAU - Rockson, Stanley G
AU  - Rockson SG
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokines)
RN  - 0 (Interleukin-8)
RN  - 0 (NF-kappa B)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
SB  - IM
MH  - Animals
MH  - Biomarkers/analysis
MH  - Cardiovascular Diseases/*metabolism/*physiopathology
MH  - Cell Communication/drug effects
MH  - Chemokine CCL2/physiology
MH  - Chemokines/*physiology
MH  - Endothelium, Vascular/cytology/metabolism
MH  - Forecasting
MH  - Humans
MH  - Interleukin-8/physiology
MH  - NF-kappa B/pharmacology
MH  - Tissue Inhibitor of Metalloproteinase-1/drug effects/physiology
RF  - 103
EDAT- 2002/01/05 10:00
MHDA- 2002/04/06 10:01
CRDT- 2002/01/05 10:00
PHST- 2002/01/05 10:00 [pubmed]
PHST- 2002/04/06 10:01 [medline]
PHST- 2002/01/05 10:00 [entrez]
AID - S0021-9150(01)00571-8 [pii]
AID - 10.1016/s0021-9150(01)00571-8 [doi]
PST - ppublish
SO  - Atherosclerosis. 2002 Jan;160(1):91-102. doi: 10.1016/s0021-9150(01)00571-8.