PMID- 11756006
OWN - NLM
STAT- MEDLINE
DCOM- 20020308
LR  - 20231113
IS  - 0198-8859 (Print)
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 62
IP  - 12
DP  - 2001 Dec
TI  - The major histocompatibility complex influences the ethiopathogenesis of MS-like 
      disease in primates at multiple levels.
PG  - 1371-81
AB  - Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease primarily 
      affecting the central nervous system. Of the many candidate polymorphic major 
      histocompatibility complex (MHC) and non-MHC genes contributing to disease 
      susceptibility, including those encoding effector (cytokines and chemokines) or 
      receptor molecules within the immune system (MHC, TCR, Ig or FcR), human 
      leukocyte antigen (HLA) class II genes have the most significant influence. In 
      this article we put forward the hypothesis that the influence of HLA genes on the 
      risk to develop MS is actually the sum of multiple antigen presenting cell (APC) 
      and T-cell interactions involving HLA class I and class II molecules. This 
      article will also discuss that, because of the genetic and immunologic similarity 
      to humans, autoimmune models of MS in non-human primates are the experimental 
      models "par excellence" to test this hypothesis.
FAU - 't Hart, B A
AU  - 't Hart BA
AD  - Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, The 
      Netherlands. hart@bprc.nl
FAU - Brok, H P
AU  - Brok HP
FAU - Amor, S
AU  - Amor S
FAU - Bontrop, R E
AU  - Bontrop RE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Animals
MH  - Antigen-Presenting Cells/immunology
MH  - Autoantibodies/immunology
MH  - Brain/immunology
MH  - *Disease Models, Animal
MH  - Encephalomyelitis, Autoimmune, Experimental/etiology/genetics
MH  - Female
MH  - Humans
MH  - *Major Histocompatibility Complex/immunology
MH  - Male
MH  - Mice
MH  - Multiple Sclerosis/*genetics
MH  - Myelin Sheath/immunology
MH  - Risk Factors
MH  - T-Lymphocytes/immunology
PMC - PMC7135550
EDAT- 2002/01/05 10:00
MHDA- 2002/03/09 10:01
PMCR- 2001/12/20
CRDT- 2002/01/05 10:00
PHST- 2002/01/05 10:00 [pubmed]
PHST- 2002/03/09 10:01 [medline]
PHST- 2002/01/05 10:00 [entrez]
PHST- 2001/12/20 00:00 [pmc-release]
AID - S0198-8859(01)00346-9 [pii]
AID - 10.1016/s0198-8859(01)00346-9 [doi]
PST - ppublish
SO  - Hum Immunol. 2001 Dec;62(12):1371-81. doi: 10.1016/s0198-8859(01)00346-9.