PMID- 11756852
OWN - NLM
STAT- MEDLINE
DCOM- 20020219
LR  - 20191105
IS  - 1070-8022 (Print)
IS  - 1070-8022 (Linking)
VI  - 21
IP  - 4
DP  - 2001 Dec
TI  - Polarimetric nerve fiber analysis in patients with visible optic nerve head 
      drusen.
PG  - 245-9
AB  - OBJECTIVE: To evaluate the effect of visible optic nerve head drusen (ONHD) on 
      retinal nerve fiber layer (RNFL) thickness retardation by using scanning laser 
      polarimetry. METHODS: Twenty-three eyes of 13 patients with visible ONHD and 26 
      eyes of 13 age- and sex-matched control subjects were involved in the study. 
      Ophthalmologic examination, scanning laser polarimetry with nerve fiber analyser 
      (NFA) type II GDX, automated Humphrey visual field testing, and red-free fundus 
      photography were performed. Eyes with ONHD were classified from grade 0 to III 
      according to the amount of visible drusen. Thus, grade 0 discs had no clinically 
      visible ONHD and grade III discs represented the presence of dense drusen. 
      RESULTS: Measurements with NFA of RNFL thickness retardation showed significant 
      decrease in eyes with visible ONHD compared with control eyes (P < 0.05). 
      Although no significant difference was found between grade I and grade II discs 
      regarding NFA measurements, grade III discs had significantly lower values, 
      indicating the greater amount of RNFL loss with higher grade ONHD. Documentation 
      of increased percentage of visual field defects with higher grade drusen was also 
      in accordance with this finding. CONCLUSIONS: NFA can quantitatively detect the 
      decrease in retardation of RNFL thickness in eyes with visible ONHD and can be 
      used as an indicator of nerve fiber layer loss in these cases.
FAU - Tatlipinar, S
AU  - Tatlipinar S
AD  - Department of Ophthalmology, Hacettepe University School of Medicine, Ankara, 
      Turkey.
FAU - Kadayifcilar, S
AU  - Kadayifcilar S
FAU - Bozkurt, B
AU  - Bozkurt B
FAU - Gedik, S
AU  - Gedik S
FAU - Karaagaoglu, E
AU  - Karaagaoglu E
FAU - Orhan, M
AU  - Orhan M
FAU - Irkec, M
AU  - Irkec M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Neuroophthalmol
JT  - Journal of neuro-ophthalmology : the official journal of the North American 
      Neuro-Ophthalmology Society
JID - 9431308
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Female
MH  - Humans
MH  - Lasers
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Optic Disk Drusen/classification/*diagnosis
MH  - Retinal Ganglion Cells/*pathology
MH  - Visual Field Tests/methods
MH  - Visual Fields
EDAT- 2002/01/05 10:00
MHDA- 2002/02/20 10:01
CRDT- 2002/01/05 10:00
PHST- 2002/01/05 10:00 [pubmed]
PHST- 2002/02/20 10:01 [medline]
PHST- 2002/01/05 10:00 [entrez]
AID - 10.1097/00041327-200112000-00003 [doi]
PST - ppublish
SO  - J Neuroophthalmol. 2001 Dec;21(4):245-9. doi: 10.1097/00041327-200112000-00003.