PMID- 11756990
OWN - NLM
STAT- MEDLINE
DCOM- 20020128
LR  - 20061115
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 185
IP  - 1
DP  - 2002 Jan 1
TI  - Associations between human leukocyte antigens and nonresponsiveness to influenza 
      vaccine.
PG  - 114-7
AB  - Influenza remains a major cause of morbidity and mortality, particularly in 
      at-risk groups where vaccination reduces complications of infection but is not 
      universally protective. In order to determine whether human leukocyte antigen 
      (HLA) class II polymorphisms modulate anti-influenza antibody responses to 
      vaccination, a cohort of HLA-typed at-risk donors was investigated. The subjects 
      were recruited from a single urban family practice. Hemagglutination-inhibition 
      (HAI) titers were measured immediately before and 28 days after subunit 
      vaccination. Nonresponsiveness was defined as failure to mount an HAI response to 
      any component of the trivalent influenza vaccine. When the nonresponders and 
      responders with HLA class II were compared, the nonresponder group had more 
      HLA-DRB1*07-positive donors (13/32 vs. 6/41 responders; P=.016, Fisher's exact 
      test) and fewer HLA-DQB1*0603-9/14-positive donors (2/32 vs. 14/41 responders; 
      P=.0045). Thus, polymorphisms in HLA class II molecules appear to modulate 
      antibody responses to influenza vaccination.
FAU - Gelder, Colin M
AU  - Gelder CM
AD  - Section of Infection and Immunity, University of Wales College of Medicine, 
      Cardiff CF14 4XX, Wales, United Kingdom. viralimmunol@cf.ac.uk
FAU - Lambkin, Rob
AU  - Lambkin R
FAU - Hart, Keith W
AU  - Hart KW
FAU - Fleming, Douglas
AU  - Fleming D
FAU - Williams, O Martin
AU  - Williams OM
FAU - Bunce, Mike
AU  - Bunce M
FAU - Welsh, Kenneth I
AU  - Welsh KI
FAU - Marshall, Sara E
AU  - Marshall SE
FAU - Oxford, John
AU  - Oxford J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20011214
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Antibodies, Viral)
RN  - 0 (HLA-D Antigens)
RN  - 0 (Influenza Vaccines)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antibodies, Viral/blood
MH  - Antibody Formation
MH  - Genes, MHC Class II/*genetics
MH  - HLA-D Antigens
MH  - Histocompatibility Testing
MH  - Humans
MH  - Influenza Vaccines/*immunology
MH  - Influenza, Human/*prevention & control
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - *Vaccination
EDAT- 2002/01/05 10:00
MHDA- 2002/01/29 10:01
CRDT- 2002/01/05 10:00
PHST- 2001/06/05 00:00 [received]
PHST- 2001/09/12 00:00 [revised]
PHST- 2002/01/05 10:00 [pubmed]
PHST- 2002/01/29 10:01 [medline]
PHST- 2002/01/05 10:00 [entrez]
AID - JID010636 [pii]
AID - 10.1086/338014 [doi]
PST - ppublish
SO  - J Infect Dis. 2002 Jan 1;185(1):114-7. doi: 10.1086/338014. Epub 2001 Dec 14.