PMID- 11757760
OWN - NLM
STAT- MEDLINE
DCOM- 20020327
LR  - 20220408
IS  - 0918-2918 (Print)
IS  - 0918-2918 (Linking)
VI  - 40
IP  - 11
DP  - 2001 Nov
TI  - Evaluation of renal biopsy samples of patients with diabetic nephropathy.
PG  - 1077-84
AB  - OBJECTIVE: To evaluate the usefulness of renal biopsy in the overall management 
      of patients with diabetes mellitus (DM), we examined the relationship between the 
      clinical parameters and histopathological findings of renal biopsy samples. 
      METHODS: Renal biopsy specimens were obtained from 109 type 2 diabetic patients 
      with proteinuria. Samples were divided into the following two groups: Diabetic 
      Nephropathy (DN) group (n=80) had typical diabetic lesions without other renal 
      diseases, complication group (n=29) had diabetic lesions with other renal 
      diseases. Furthermore, DN group was subdivided into two subgroups: slow 
      progressive group (SP group, n=32), the level of serum creatinine (s-Cr) was 
      normal at the time of renal biopsy and three years after renal biopsy, and fast 
      progressive group (FP group, n=14), the level of s-Cr was normal at the time of 
      renal biopsy but more than doubled three years after renal biopsy. RESULTS: The 
      level of total protein was significantly lower and HbA1c significantly higher in 
      the DN group than in the Complication group. However, other clinical parameters 
      were not significantly different between the two groups. Urinary protein, 
      systolic and diastolic blood pressure in FP group were significantly higher than 
      in SP group. The percentage of sclerotic glomeruli, the severity of mesangial 
      expansion, tubular injury and cell infiltration were significantly greater in FP 
      than in SP group. CONCLUSIONS: Our results indicated that a complete evaluation 
      of renal pathology in DM could not be made by clinical parameters only, and that 
      the progression of DN could be accurately predicted by histopathological 
      evaluation. Therefore, this study emphasizes the importance of renal biopsy in 
      the overall management of patients with DM and/or DN.
FAU - Suzuki, D
AU  - Suzuki D
AD  - Department of Internal Medicine, School of Medicine, Tokai University, Isehara, 
      Kanagawa.
FAU - Takano, H
AU  - Takano H
FAU - Toyoda, M
AU  - Toyoda M
FAU - Umezono, T
AU  - Umezono T
FAU - Uehara, G
AU  - Uehara G
FAU - Sakai, T
AU  - Sakai T
FAU - Zhang, S Y
AU  - Zhang SY
FAU - Mori, Y
AU  - Mori Y
FAU - Yagame, M
AU  - Yagame M
FAU - Endoh, M
AU  - Endoh M
FAU - Sakai, H
AU  - Sakai H
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
SB  - IM
CIN - Intern Med. 2001 Nov;40(11):1071-2. PMID: 11757757
MH  - Adult
MH  - Biopsy
MH  - Diabetic Nephropathies/*pathology
MH  - Disease Progression
MH  - Female
MH  - Glomerular Mesangium/pathology
MH  - Humans
MH  - Kidney/*pathology
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
EDAT- 2002/01/05 10:00
MHDA- 2002/03/28 10:01
CRDT- 2002/01/05 10:00
PHST- 2002/01/05 10:00 [pubmed]
PHST- 2002/03/28 10:01 [medline]
PHST- 2002/01/05 10:00 [entrez]
AID - 10.2169/internalmedicine.40.1077 [doi]
PST - ppublish
SO  - Intern Med. 2001 Nov;40(11):1077-84. doi: 10.2169/internalmedicine.40.1077.