PMID- 11758971
OWN - NLM
STAT- MEDLINE
DCOM- 20020107
LR  - 20221207
IS  - 1078-0297 (Print)
IS  - 1078-0297 (Linking)
VI  - 108
IP  - 1-2
DP  - 2000 Jul-Aug
TI  - Progression of carotid atherosclerosis and the role of endothelin in diabetic 
      patients.
PG  - 27-37
AB  - An increased thickness of the carotid artery wall is thought to be a sign of 
      early atherosclerosis. Since vascular endothelium is the site of formation of 
      several substances, we have investigated the rate of progression of carotid 
      atherosclerosis and the contribution of endothelin (ET-1), lipid peroxides 
      [measured as thiobarbituric acid reacting species (TBARS)] and 
      6-keto-Prostaglandin-F1A (6-keto-PG-F1A) at baseline and after 30-months. Fifty 
      patients with Type 2 diabetes without evidence of macroangiopathy, hypertension, 
      proteinuria or proliferative retinopathy, and 27 healthy, non-diabetic persons 
      were studied. Arterial wall thickness was measured as the mean of the maximum 
      intimal-medial thickness (IMT) in 16 carotid segments by b-mode ultrasound. The 
      IMT values was significantly increased in diabetic subjects (at baseline: 1110 
      +/- 310 microm, after 30 months: 1260 +/- 280 microm, p < 0.01), but not in 
      control subjects (1100 +/- 280 microm, 1200 +/- 290 microm, respectively). At 
      baseline time both groups had similar levels of ET-1, TBARS and 6-keto-PG-F1A. In 
      30-months follow-up, the ET-1 level 8.0 pmol/l (5.8-10.7) was significantly 
      elevated in diabetic subjects, compared with the level at baseline time 7.43 
      pmol/l (4.8-11.1) p < 0.01. No significant differences were found in the other 
      examined parameters in the studied groups. Although insulin levels remained 
      unchanged in the two studied groups, in 30 months follow-up, the insulin level in 
      the diabetic subjects, 92.4 +/- 35.1 pmol/l was significantly elevated compared 
      with those of control subjects 76.0 +/- 31.0 pmol/l, p < 0.05. In conclusion, 
      endothelis is the main associate of the change of IMT value over 30 months in 
      diabetic patients, in whom the extent of atherosclerosis was significantly 
      greater than in control subjects.
FAU - Migdalis, I N
AU  - Migdalis IN
AD  - Department of Diabetes, NIMTS Hospital, Athens, Greece.
FAU - Kalogeropoulou, K
AU  - Kalogeropoulou K
FAU - Iiopoulou, V
AU  - Iiopoulou V
FAU - Varvarigos, N
AU  - Varvarigos N
FAU - Karmaniolas, K D
AU  - Karmaniolas KD
FAU - Mortzos, G
AU  - Mortzos G
FAU - Cordopatis, P
AU  - Cordopatis P
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Res Commun Mol Pathol Pharmacol
JT  - Research communications in molecular pathology and pharmacology
JID - 9437512
RN  - 0 (Blood Glucose)
RN  - 0 (Endothelins)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 0 (Lipid Peroxides)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 58962-34-8 (6-Ketoprostaglandin F1 alpha)
SB  - IM
MH  - 6-Ketoprostaglandin F1 alpha/blood
MH  - Arteriosclerosis/*pathology
MH  - Blood Glucose/metabolism
MH  - Body Mass Index
MH  - Carotid Arteries/pathology
MH  - Carotid Artery Diseases/*pathology
MH  - Diabetes Mellitus, Type 2/*pathology
MH  - Disease Progression
MH  - Endothelins/*physiology
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Insulin/blood
MH  - Lipid Peroxides/physiology
MH  - Male
MH  - Middle Aged
MH  - Thiobarbituric Acid Reactive Substances/metabolism
EDAT- 2002/01/05 10:00
MHDA- 2002/01/10 10:01
CRDT- 2002/01/05 10:00
PHST- 2002/01/05 10:00 [pubmed]
PHST- 2002/01/10 10:01 [medline]
PHST- 2002/01/05 10:00 [entrez]
PST - ppublish
SO  - Res Commun Mol Pathol Pharmacol. 2000 Jul-Aug;108(1-2):27-37.