PMID- 11765028
OWN - NLM
STAT- MEDLINE
DCOM- 20020430
LR  - 20221207
IS  - 0146-4760 (Print)
IS  - 0146-4760 (Linking)
VI  - 25
IP  - 8
DP  - 2001 Nov-Dec
TI  - Fatal 4-MTA intoxication: development of a liquid chromatographic-tandem mass 
      spectrometric assay for multiple matrices.
PG  - 705-10
AB  - The case history and toxicological findings of an overdose fatality involving 
      4-methylthioamphetamine (4-MTA) and 3,4-methylenedioxymethamphetamine (MDMA) are 
      reported along with a description of the analytical method. Detection and 
      quantitation of 4-MTA and MDMA were performed by liquid chromatography-tandem 
      mass spectrometry using phentermine as internal standard. Application of this 
      technique to a variety of matrices allowed an insight in the distribution of 
      4-MTA. Several blood samples including femoral vein blood (5.23 mg/L), urine 
      (95.5 mg/L), vitreous humor (1.31 mg/L), bile (36.4 mg/L), and numerous tissue 
      samples such as liver (30.8 mg/kg), spleen (4.10 mg/kg), and frontal lobe (31.7 
      mg/kg) were assayed. These values indicated that 4-MTA could be identified as the 
      cause of this fatality, whereas the concentrations of MDMA, also described, are 
      less important because the concentrations found are lower. This case reports, for 
      the first time, an extensive toxicological analysis of 4-MTA, by which the data 
      presented may shed some light on the distribution of 4-MTA.
FAU - Decaestecker, T
AU  - Decaestecker T
AD  - Laboratoria voor Medische Biochemie en voor Klinische Analyse, Universiteit Gent, 
      Belgium.
FAU - De Letter, E
AU  - De Letter E
FAU - Clauwaert, K
AU  - Clauwaert K
FAU - Bouche, M P
AU  - Bouche MP
FAU - Lambert, W
AU  - Lambert W
FAU - Van Bocxlaer, J
AU  - Van Bocxlaer J
FAU - Piette, M
AU  - Piette M
FAU - Van den Eeckhout, E
AU  - Van den Eeckhout E
FAU - Van Peteghem, C
AU  - Van Peteghem C
FAU - De Leenheer, A
AU  - De Leenheer A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Anal Toxicol
JT  - Journal of analytical toxicology
JID - 7705085
RN  - 0 (Amphetamines)
RN  - 0 (Hallucinogens)
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - 6JP2T8KXTR (4-methylthioamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adult
MH  - Amphetamines/analysis/pharmacokinetics/*poisoning
MH  - Autopsy
MH  - Chromatography, Liquid
MH  - *Drug Overdose
MH  - Fatal Outcome
MH  - Femoral Vein/chemistry
MH  - Hallucinogens/analysis/pharmacokinetics/*poisoning
MH  - Humans
MH  - Male
MH  - Mass Spectrometry
MH  - N-Methyl-3,4-methylenedioxyamphetamine/analysis/pharmacokinetics/*poisoning
MH  - Selective Serotonin Reuptake Inhibitors/analysis/pharmacokinetics/*poisoning
MH  - Tissue Distribution
MH  - Vitreous Body/chemistry
EDAT- 2002/01/05 10:00
MHDA- 2002/05/01 10:01
CRDT- 2002/01/05 10:00
PHST- 2002/01/05 10:00 [pubmed]
PHST- 2002/05/01 10:01 [medline]
PHST- 2002/01/05 10:00 [entrez]
AID - 10.1093/jat/25.8.705 [doi]
PST - ppublish
SO  - J Anal Toxicol. 2001 Nov-Dec;25(8):705-10. doi: 10.1093/jat/25.8.705.