PMID- 11766834
OWN - NLM
STAT- MEDLINE
DCOM- 20020313
LR  - 20190921
IS  - 0886-0440 (Print)
IS  - 0886-0440 (Linking)
VI  - 16
IP  - 2
DP  - 2001 Mar-Apr
TI  - Intermediate-term results after partial left ventriculectomy for end-stage 
      dilated cardiomyopathy: is there a survival benefit?
PG  - 153-8
AB  - BACKGROUND: The mortality of congestive heart failure remains high despite 
      advances in medical therapy. Partial left ventriculectomy (PLV) has been 
      advocated as a surgical alternative for select patients with dilated 
      cardiomyopathy. METHODS: A prospective clinical trial of PLV for patients with 
      end-stage idiopathic dilated cardiomyopathy was performed. Inclusion criteria 
      were left ventricular end-diastolic diameter (LVEDD) greater than 7 cm, 
      refractory New York Heart Association (NYHA) Class IV symptoms, and severely 
      depressed exercise oxygen consumption. RESULTS: Twenty patients underwent PLV 
      with mean follow-up of 21.1 months. Sixteen were male; mean age was 50.1 years 
      +/- 12.0 years (range 25-67 years). Left ventricle (LV) ejection fraction 
      improved after surgery from 14.1% +/- 4.7% to 24.1% +/- 3.1% (p < 0.05, t-test) 
      and this improvement persisted up to 3 years after operation. LVEDD and NYHA 
      Class also were notably improved. There were two early deaths for an operative 
      mortality of 10% (2 of 20 patients). Nine patients after initial improvement in 
      clinical status and LV function developed worsening congestive heart failure 
      (CHF). Six of the 9 ultimately died of complications secondary to CHF. One-, 2-, 
      and 3-year survival rates were 84%, 64%, and 40%, respectively, by Kaplan-Meier 
      analysis. The other three patients required listing for transplantation because 
      of recurrent NYHA Class IV symptoms. Freedom from death or the need for listing 
      for transplantation at 1, 2, and 3 years was 65%, 53%, and 33%, respectively. The 
      remaining nine patients all had improvement in their NYHA classification. 
      CONCLUSIONS: PLV can be performed with acceptable early and intermediate term 
      mortality; survival compares favorably to reports of similar groups of patients 
      treated with medical therapy alone.
FAU - Etoch, S W
AU  - Etoch SW
AD  - Department of Surgery, University of Louisville and the Jewish Hospital Heart and 
      Lung Institute, Kentucky, USA. swetoc01@athena.louisville.edu
FAU - Cerito, P
AU  - Cerito P
FAU - Henahan, B J
AU  - Henahan BJ
FAU - Gray, L A Jr
AU  - Gray LA Jr
FAU - Dowling, R D
AU  - Dowling RD
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - J Card Surg
JT  - Journal of cardiac surgery
JID - 8908809
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiac Surgical Procedures/*adverse effects/*methods
MH  - Cardiomyopathy, Dilated/mortality/pathology/*physiopathology/*surgery
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Recurrence
MH  - Severity of Illness Index
MH  - *Stroke Volume
MH  - Survival Rate
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2002/01/05 10:00
MHDA- 2002/03/14 10:01
CRDT- 2002/01/05 10:00
PHST- 2002/01/05 10:00 [pubmed]
PHST- 2002/03/14 10:01 [medline]
PHST- 2002/01/05 10:00 [entrez]
AID - 10.1111/j.1540-8191.2001.tb00501.x [doi]
PST - ppublish
SO  - J Card Surg. 2001 Mar-Apr;16(2):153-8. doi: 10.1111/j.1540-8191.2001.tb00501.x.