PMID- 11768032
OWN - NLM
STAT- MEDLINE
DCOM- 20020103
LR  - 20190916
IS  - 0735-7907 (Print)
IS  - 0735-7907 (Linking)
VI  - 19
IP  - 8
DP  - 2001
TI  - Effect of hyperthermia on AKR lymphoma variants differing in degree of 
      malignancy.
PG  - 791-8
AB  - The effect of hyperthermic treatment on AKR lymphoma cells of varying malignancy 
      was investigated. Tumor cells were pretreated at 37 or 43 degrees C and then 
      injected to mice. The effect on the highly malignant variant, TAU-38, was 
      compared to that on the low-malignancy variant, TAU-39, following both 
      subcutaneous (s.c.) and intravenous (i.v.) inoculation. Hyperthermia showed no 
      effect on the TAU-39 variant following s.c. inoculation on the primary tumors or 
      mice survival, but the TAU-38 variant exhibited a significant delay of tumor 
      appearance following treatment, namely, decreased tumor size and increased life 
      span. Following i.v. inoculation, in both variants, hyperthermia caused a 
      significant decrease in metastatic spread and an increased life span. We conclude 
      that hyperthermia, in addition to exerting a greater effect on the 
      high-malignancy variant, acts at the late phases of metastasis. Hyperthermia 
      might therefore have a place in the management of cancer in its advanced 
      disseminated phase.
FAU - Sharabi, Y
AU  - Sharabi Y
AD  - Department of Internal Medicine D, The Chaim Sheba Medical Center, Tel Hashomer, 
      Israel. yina@internet-zahav.net
FAU - Klorin, G
AU  - Klorin G
FAU - Leibovici, J
AU  - Leibovici J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Cancer Invest
JT  - Cancer investigation
JID - 8307154
SB  - IM
MH  - Animals
MH  - *Hyperthermia, Induced
MH  - Lymphoma/mortality/pathology/*therapy
MH  - Mice
MH  - Mice, Inbred AKR
MH  - Survival Rate
EDAT- 2002/01/05 10:00
MHDA- 2002/01/05 10:01
CRDT- 2002/01/05 10:00
PHST- 2002/01/05 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2002/01/05 10:00 [entrez]
AID - 10.1081/cnv-100107740 [doi]
PST - ppublish
SO  - Cancer Invest. 2001;19(8):791-8. doi: 10.1081/cnv-100107740.