PMID- 11768164
OWN - NLM
STAT- MEDLINE
DCOM- 20020529
LR  - 20190814
IS  - 0024-4201 (Print)
IS  - 0024-4201 (Linking)
VI  - 36
IP  - 10
DP  - 2001 Oct
TI  - Transforming growth factor beta in human milk does not change in response to 
      modest intakes of docosahexaenoic acid.
PG  - 1179-81
AB  - Long-chain polyunsaturated fatty acids have been associated with aspects of 
      immune regulation including cytokine production. The purpose of this study was to 
      investigate the effect of maternal dietary supplementation with tuna oil, rich in 
      docosahexaenoic acid (DHA), on the concentration of transforming growth factor 
      beta 1 (TGFbeta1) and TGFbeta2 in breast milk. In this randomized, dietary 
      intervention trial, mothers of term infants consumed a daily supplement of 2000 
      mg oil containing either placebo (n = 40), 300 mg DHA (n = 40), or 600 mg DHA (n 
      = 40). The DHA increase in milk and plasma was proportional to dietary DHA. There 
      was no relationship between milk DHA status and TGFbeta1 and TGFbeta2 levels.
FAU - Hawkes, J S
AU  - Hawkes JS
AD  - Child Nutrition Research Centre, Flinders Medical Centre, Bedford Park, South 
      Australia, Australia.
FAU - Bryan, D L
AU  - Bryan DL
FAU - Neumann, M A
AU  - Neumann MA
FAU - Makrides, M
AU  - Makrides M
FAU - Gibson, R A
AU  - Gibson RA
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Lipids
JT  - Lipids
JID - 0060450
RN  - 0 (Dietary Fats, Unsaturated)
RN  - 0 (Fish Oils)
RN  - 0 (Placebos)
RN  - 0 (TGFB1 protein, human)
RN  - 0 (TGFB2 protein, human)
RN  - 0 (Transforming Growth Factor beta)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 0 (Transforming Growth Factor beta2)
RN  - 25167-62-8 (Docosahexaenoic Acids)
SB  - IM
MH  - Animals
MH  - Dietary Fats, Unsaturated/*administration & dosage
MH  - Dietary Supplements
MH  - Docosahexaenoic Acids/*administration & dosage/analysis/blood
MH  - Double-Blind Method
MH  - Female
MH  - Fish Oils/administration & dosage
MH  - Humans
MH  - Milk, Human/*metabolism
MH  - Placebos
MH  - Prospective Studies
MH  - Transforming Growth Factor beta/analysis/*metabolism
MH  - Transforming Growth Factor beta1
MH  - Transforming Growth Factor beta2
MH  - Tuna
EDAT- 2002/01/05 10:00
MHDA- 2002/05/30 10:01
CRDT- 2002/01/05 10:00
PHST- 2002/01/05 10:00 [pubmed]
PHST- 2002/05/30 10:01 [medline]
PHST- 2002/01/05 10:00 [entrez]
AID - 10.1007/s11745-001-0830-5 [doi]
PST - ppublish
SO  - Lipids. 2001 Oct;36(10):1179-81. doi: 10.1007/s11745-001-0830-5.