PMID- 11770036
OWN - NLM
STAT- MEDLINE
DCOM- 20020617
LR  - 20190916
IS  - 1073-2322 (Print)
IS  - 1073-2322 (Linking)
VI  - 16
IP  - 6
DP  - 2001 Dec
TI  - Interleukin-18 plasma levels are increased in patients with sepsis compared to 
      severely injured patients.
PG  - 411-4
AB  - Interleukin-18 (IL-18) appears to play a critical role in cytokine-induced organ 
      failure during endotoxemia in animal models. Therefore, plasma samples from 
      patients with severe trauma and sepsis were examined for the presence of IL-18. 
      Significantly elevated plasma IL-18 concentrations were found in patients with 
      sepsis compared to severely injured patients and healthy humans. Septic patients 
      who died and patients with septic shock exhibited higher levels of IL-18 than 
      survivors and septic patients without shock. In addition, septic patients with 
      gram-positive infections had significantly higher IL-18 plasma levels than 
      patients with gram-negative infection. These findings were confirmed by whole 
      blood assay from healthy humans where Staphylococcus aureus markedly (P < 0.05) 
      increased the release of IL-18 in whole blood ex vivo, while endotoxin was 
      ineffective. Although obtained from a small patient group, these results suggest 
      that IL-18 production may discriminate between gram-positive and gram-negative 
      sepsis, and that increased IL-18 appearance may be associated with an adverse 
      outcome in septic patients.
FAU - Oberholzer, A
AU  - Oberholzer A
AD  - Division of Trauma Surgery, University Hospital Zurich, Switzerland.
FAU - Steckholzer, U
AU  - Steckholzer U
FAU - Kurimoto, M
AU  - Kurimoto M
FAU - Trentz, O
AU  - Trentz O
FAU - Ertel, W
AU  - Ertel W
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Shock
JT  - Shock (Augusta, Ga.)
JID - 9421564
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Female
MH  - Gram-Negative Bacterial Infections/immunology
MH  - Gram-Positive Bacterial Infections/immunology
MH  - Humans
MH  - Interleukin-18/*blood
MH  - Male
MH  - Middle Aged
MH  - Sepsis/*immunology
MH  - Shock, Septic/immunology
MH  - Staphylococcal Infections/immunology
MH  - Staphylococcus aureus/immunology/pathogenicity
MH  - Wounds and Injuries/*immunology
EDAT- 2002/01/05 10:00
MHDA- 2002/06/18 10:01
CRDT- 2002/01/05 10:00
PHST- 2002/01/05 10:00 [pubmed]
PHST- 2002/06/18 10:01 [medline]
PHST- 2002/01/05 10:00 [entrez]
AID - 10.1097/00024382-200116060-00001 [doi]
PST - ppublish
SO  - Shock. 2001 Dec;16(6):411-4. doi: 10.1097/00024382-200116060-00001.