PMID- 11770799
OWN - NLM
STAT- MEDLINE
DCOM- 20020507
LR  - 20131121
IS  - 0301-0430 (Print)
IS  - 0301-0430 (Linking)
VI  - 56
IP  - 6
DP  - 2001 Dec
TI  - Association of the DD genotype and development of Japanese type 2 diabetic 
      nephropathy.
PG  - 475-80
AB  - We determined the insertion/deletion (I/D) polymorphism of the 
      angiotensin-coverting enzyme (ACE) gene in a multicenter trial of ethnically 
      homogeneous Japanese type 2 diabetes mellitus (DM) patients. All patients (n = 
      748) were divided into 5 groups as follows: group I (normoalbuminuric patients), 
      group II (microalbuminuric patients), group III (overt albuminuric patients with 
      serum creatinine (s-Cr) levels of less than 1.2 mg/dl), group IV (overt 
      albuminuric patients with s-Cr levels of more than 1.3 mg/dl but excluding 
      hemodialysis patients), and group V (hemodialysis patients). We selected patients 
      with a diabetic duration of more than 15 years in the mild stage (groups I and 
      II), but placed no limits on those in the advanced and end-stages (groups III, IV 
      and V). The frequency of the DD genotype was slightly higher in the advanced and 
      end stages. The frequency of the DD genotype in the mild stage differed from that 
      in the end stage (II/ID/DD 47.8%/41.0%/11.2% vs. 37.0 %/43.3%/19.7% p = 0.07, II 
      + ID/DD 88.8%/11.2% vs. 80.3%/19.7%, p < 0.05). D allele frequency in the mild 
      stage also differed from that in the end stage (I/D 68.3%/31.7% vs. 58.7%/41.3%, 
      p < 0.02). The presence of the DD genotype increased the risk of end-stage renal 
      disease (ESRD) more than that of the other genotypes (odds ratio ID/II = 1.37, 
      95% CI 0.82-2.27; DD/II = 2.27, 95% CI 1.12-4.61). It appears that the DD 
      genotype is associated with progression of Japanese type 2 diabetic nephropathy.
FAU - Gohda, T
AU  - Gohda T
AD  - Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan.
FAU - Makita, Y
AU  - Makita Y
FAU - Shike, T
AU  - Shike T
FAU - Kobayashi, M
AU  - Kobayashi M
FAU - Funabiki, K
AU  - Funabiki K
FAU - Haneda, M
AU  - Haneda M
FAU - Kikkawa, R
AU  - Kikkawa R
FAU - Watanabe, T
AU  - Watanabe T
FAU - Baba, T
AU  - Baba T
FAU - Yoshida, H
AU  - Yoshida H
FAU - Tomino, Y
AU  - Tomino Y
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PL  - Germany
TA  - Clin Nephrol
JT  - Clinical nephrology
JID - 0364441
RN  - AYI8EX34EU (Creatinine)
RN  - EC 3.4.15.1 (Peptidyl-Dipeptidase A)
SB  - IM
MH  - Aged
MH  - Blood Pressure
MH  - Case-Control Studies
MH  - Creatinine/blood
MH  - Diabetes Mellitus, Type 2/complications/*genetics
MH  - Diabetic Nephropathies/etiology/*genetics
MH  - Disease Progression
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Japan
MH  - Kidney Failure, Chronic/etiology/*genetics
MH  - Male
MH  - Middle Aged
MH  - Peptidyl-Dipeptidase A/*genetics
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic
EDAT- 2002/01/05 10:00
MHDA- 2002/05/08 10:01
CRDT- 2002/01/05 10:00
PHST- 2002/01/05 10:00 [pubmed]
PHST- 2002/05/08 10:01 [medline]
PHST- 2002/01/05 10:00 [entrez]
PST - ppublish
SO  - Clin Nephrol. 2001 Dec;56(6):475-80.