PMID- 11771188
OWN - NLM
STAT- MEDLINE
DCOM- 20020110
LR  - 20150901
IS  - 2072-0939 (Print)
IS  - 2072-0939 (Linking)
VI  - 24
IP  - 10
DP  - 2001 Oct
TI  - Selective termination of aneuploidy utilizing rapid fluorescence in situ 
      hybridization detection techniques.
PG  - 646-50
AB  - Twin pregnancy following assisted reproductive technology with a euploid fetus 
      and a coexisting aneuploid co-twin constitutes a conflicting situation; 
      therefore, it is important for the genetic constitution of each co-twin to be 
      diagnosed accurately and promptly for parental genetic counseling and subsequent 
      aggressive management. A 35-year-old woman, gravida 1, with a 2-year history of 
      infertility, presented bilateral fallopian tubal obstruction at her infertility 
      workups, for which she received in vitro fertilization; subsequently she 
      conceived a twin pregnancy. She underwent genetic amniocentesis at 16 weeks' 
      gestation, as indicated by an advanced maternal age. Presented with the diagnosis 
      of twin pregnancy with discordancy for trisomy 21, a rapid fluorescence in situ 
      hybridization (FISH) technique for aneuploidy mapping was applied for subsequent 
      abdominal selective fetal reduction. The FISH technique facilitates the rapid 
      analysis of uncultured amniocytes. Normal (disomic) and trisomic samples can be 
      distinguished clearly and rapidly for subsequent selective fetocide. The FISH 
      technique is an important tool in prenatal diagnosis and clinical applications.
FAU - Lee, Y Y
AU  - Lee YY
AD  - Department of Obstetrics and Gynecology, Chung Shan Medical & Dental College 
      Hospital, 23, Section 1, Taichung-Kang Road, Taichung 403, Taiwan, R.O.C. 
      cshlee356@yahoo.com
FAU - Chen, C I
AU  - Chen CI
FAU - Chang, H C
AU  - Chang HC
FAU - Liu, C H
AU  - Liu CH
FAU - Lee, M S
AU  - Lee MS
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - Chang Gung Med J
JT  - Chang Gung medical journal
JID - 101088034
SB  - IM
MH  - Adult
MH  - *Aneuploidy
MH  - *Diseases in Twins
MH  - Female
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Pregnancy
MH  - *Pregnancy Reduction, Multifetal
EDAT- 2002/01/05 10:00
MHDA- 2002/01/11 10:01
CRDT- 2002/01/05 10:00
PHST- 2002/01/05 10:00 [pubmed]
PHST- 2002/01/11 10:01 [medline]
PHST- 2002/01/05 10:00 [entrez]
PST - ppublish
SO  - Chang Gung Med J. 2001 Oct;24(10):646-50.