PMID- 11772338
OWN - NLM
STAT- MEDLINE
DCOM- 20030127
LR  - 20191025
IS  - 1471-2598 (Print)
IS  - 1471-2598 (Linking)
VI  - 2
IP  - 1
DP  - 2002 Jan
TI  - Dendritic cell maturation in active immunotherapy strategies.
PG  - 35-43
AB  - Dendritic cells (DCs) loaded with tumour antigen have become the centrepiece of 
      clinical trials testing active immunotherapy strategies. Important variables 
      include the source of DCs, the choice of antigens, the method of antigen loading 
      and the route and timing of administration. Recently, the requirement for and the 
      method of, DC maturation have been receiving particular attention. This is due to 
      observations from in vitro studies and animal models demonstrating that mature 
      DCs induce more potent antigen-specific T-cells responses than immature DCs. 
      Furthermore, preliminary observations in human studies suggest that immature DCs 
      might actually downregulate antigen-specific T-cell responses but mature DCs may 
      augment them. Current studies are addressing how to define DC maturation, whether 
      the variety of methods for maturation result in DCs with similar T-cell 
      stimulatory capacity, how to maintain the maturational status and whether 
      maturation in vitro before immunisation, or in vivo, after immunisation, results 
      in better DC function.
FAU - Morse, Michael A
AU  - Morse MA
AD  - Department of Mecine and Surgery, Duke University Medical Center, Durham, NC 
      27710, USA. morse004@mc.duke.edu
FAU - Mosca, Paul J
AU  - Mosca PJ
FAU - Clay, Timothy M
AU  - Clay TM
FAU - Lyerly, H Kim
AU  - Lyerly HK
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Expert Opin Biol Ther
JT  - Expert opinion on biological therapy
JID - 101125414
SB  - IM
MH  - Animals
MH  - Cell Cycle/physiology
MH  - Dendritic Cells/*immunology/physiology
MH  - Humans
MH  - Immunotherapy/*methods
MH  - Neoplasms/therapy
MH  - T-Lymphocytes/immunology
RF  - 91
EDAT- 2002/01/05 10:00
MHDA- 2003/01/28 04:00
CRDT- 2002/01/05 10:00
PHST- 2002/01/05 10:00 [pubmed]
PHST- 2003/01/28 04:00 [medline]
PHST- 2002/01/05 10:00 [entrez]
AID - 10.1517/14712598.2.1.35 [doi]
PST - ppublish
SO  - Expert Opin Biol Ther. 2002 Jan;2(1):35-43. doi: 10.1517/14712598.2.1.35.