PMID- 11772515
OWN - NLM
STAT- MEDLINE
DCOM- 20020424
LR  - 20190910
IS  - 0531-5565 (Print)
IS  - 0531-5565 (Linking)
VI  - 37
IP  - 2-3
DP  - 2002 Jan-Mar
TI  - Tumor necrosis factor-alpha-induced apoptosis in T cells from aged humans: a role 
      of TNFR-I and downstream signaling molecules.
PG  - 293-9
AB  - Tumor necrosis factor-alpha (TNF-alpha) induces apoptosis predominantly via 
      TNF-receptor I (TNF-RI). We have examined the molecular and biochemical pathways 
      of TNF-alpha-induced apoptosis in T cells from aged and young subjects. Aged 
      subjects show absolute lymphopenia and decreased numbers of both CD4+ and CD8+ T 
      cells. T cells from aged subjects show increased sensitivity to TNF-alpha-induced 
      apoptosis that is associated with increased expression of TNF-RI and decreased 
      expression of TNF-RII in both CD4+ and CD8+ T cells. Agonistic TNF-RI also 
      induced greater apoptosis in T cells from aged subjects as compared to young 
      subjects, suggesting that increased TNF-alpha-induced apoptosis in aging is 
      predominantly mediated via TNF-RI. There was an increased expression of FADD and 
      increased activation of caspase 8 and caspase 3 in lymphocytes from aged humans 
      as compared to young subjects. A role of impaired TNF-RII-mediated signaling in 
      increased apoptosis in aged subjects is also discussed.
FAU - Gupta, Sudhir
AU  - Gupta S
AD  - Cellular and Molecular Immunology and Molecular Biology Laboratories, Division of 
      Basic and Clinical Immunology, Department of Medicine, Medical Sciences 1, C-240, 
      University of California, Irvine, CA 92697, USA. sgupta@uci.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - 0 (Antigens, CD)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Aging/blood/*immunology
MH  - Animals
MH  - Antigens, CD/*immunology
MH  - Apoptosis/*immunology
MH  - CD4-Positive T-Lymphocytes/cytology/drug effects/*immunology
MH  - CD8-Positive T-Lymphocytes/cytology/drug effects/*immunology
MH  - Humans
MH  - Lymphocyte Activation/immunology
MH  - Lymphopenia/immunology
MH  - Receptors, Tumor Necrosis Factor/*immunology
MH  - Receptors, Tumor Necrosis Factor, Type I
MH  - Signal Transduction/*immunology
MH  - T-Lymphocyte Subsets/immunology
MH  - Tumor Necrosis Factor-alpha/*immunology/pharmacology
RF  - 59
EDAT- 2002/01/05 10:00
MHDA- 2002/04/25 10:01
CRDT- 2002/01/05 10:00
PHST- 2002/01/05 10:00 [pubmed]
PHST- 2002/04/25 10:01 [medline]
PHST- 2002/01/05 10:00 [entrez]
AID - S0531556501001954 [pii]
AID - 10.1016/s0531-5565(01)00195-4 [doi]
PST - ppublish
SO  - Exp Gerontol. 2002 Jan-Mar;37(2-3):293-9. doi: 10.1016/s0531-5565(01)00195-4.