PMID- 11773610
OWN - NLM
STAT- MEDLINE
DCOM- 20020129
LR  - 20071114
IS  - 0031-9333 (Print)
IS  - 0031-9333 (Linking)
VI  - 82
IP  - 1
DP  - 2002 Jan
TI  - Dendritic cells: immune regulators in health and disease.
PG  - 97-130
AB  - Dendritic cells (DCs) are bone marrow-derived cells of both lymphoid and myeloid 
      stem cell origin that populate all lymphoid organs including the thymus, spleen, 
      and lymph nodes, as well as nearly all nonlymphoid tissues and organs. Although 
      DCs are a moderately diverse set of cells, they all have potent 
      antigen-presenting capacity for stimulating naive, memory, and effector T cells. 
      DCs are members of the innate immune system in that they can respond to dangers 
      in the host environment by immediately generating protective cytokines. Most 
      important, immature DCs respond to danger signals in the microenvironment by 
      maturing, i.e., differentiating, and acquiring the capacity to direct the 
      development of primary immune responses appropriate to the type of danger 
      perceived. The powerful adjuvant activity that DCs possess in stimulating 
      specific CD4 and CD8 T cell responses has made them targets in vaccine 
      development strategies for the prevention and treatment of infections, allograft 
      reactions, allergic and autoimmune diseases, and cancer. This review addresses 
      the origins and migration of DCs to their sites of activity, their basic biology 
      as antigen-presenting cells, their roles in important human diseases and, 
      finally, selected strategies being pursued to harness their potent 
      antigen-stimulating activity.
FAU - Lipscomb, Mary F
AU  - Lipscomb MF
AD  - Department of Pathology, University of New Mexico School of Medicine, 
      Albuquerque, New Mexico 87131-5301, USA. mlipscomb@salud.unm.edu
FAU - Masten, Barbara J
AU  - Masten BJ
LA  - eng
GR  - P50-HL-56384/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Physiol Rev
JT  - Physiological reviews
JID - 0231714
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*physiology
MH  - Humans
MH  - Immune System/*physiology/*physiopathology
MH  - Immune System Diseases/*physiopathology
MH  - Neoplasms/*physiopathology
MH  - Reference Values
RF  - 397
EDAT- 2002/01/05 10:00
MHDA- 2002/01/30 10:01
CRDT- 2002/01/05 10:00
PHST- 2002/01/05 10:00 [pubmed]
PHST- 2002/01/30 10:01 [medline]
PHST- 2002/01/05 10:00 [entrez]
AID - 10.1152/physrev.00023.2001 [doi]
PST - ppublish
SO  - Physiol Rev. 2002 Jan;82(1):97-130. doi: 10.1152/physrev.00023.2001.