PMID- 11775072
OWN - NLM
STAT- MEDLINE
DCOM- 20020521
LR  - 20191025
IS  - 0272-4340 (Print)
IS  - 0272-4340 (Linking)
VI  - 21
IP  - 4
DP  - 2001 Aug
TI  - trkB-receptor activation contributes to the kainate-induced increase in BDNF mRNA 
      synthesis.
PG  - 429-35
AB  - 1. The expression of brain-derived neurotrophic factor (BDNF) mRNA is induced by 
      neuronal activity through increased intracellular calcium. As BDNF also increases 
      intracellular calcium levels through trkB activation, we have examined here 
      whether BDNF also regulates the synthesis of its own mRNA. 2. Neurotrophin mRNA 
      expression was induced with kainic acid administration in transgenic mice 
      overexpressing the dominant-negative form of BDNF receptor trkB and wild-type 
      littermates. 3. Kainate strongly induced BDNF mRNA expression in both genotypes, 
      but the up-regulation was significantly lower in transgenic mice. 4. These data 
      suggest that the synthesis of BDNF mRNA is at least partly mediated by BDNF 
      release and the activation of trkB receptors. The present findings further 
      suggest that the BDNF signaling system in brain is regulated by positive 
      feedback.
FAU - Saarelainen, T
AU  - Saarelainen T
AD  - A.I. Virtanen Institute, University of Kuopio, Finland.
FAU - Vaittinen, S
AU  - Vaittinen S
FAU - Castren, E
AU  - Castren E
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell Mol Neurobiol
JT  - Cellular and molecular neurobiology
JID - 8200709
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Excitatory Amino Acid Agonists)
RN  - 0 (Protein Isoforms)
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - SIV03811UC (Kainic Acid)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects/physiology
MH  - Brain/metabolism
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis/genetics/metabolism
MH  - Excitatory Amino Acid Agonists/administration & dosage/pharmacology
MH  - Gene Expression Regulation/genetics
MH  - Injections, Intraperitoneal
MH  - Kainic Acid/administration & dosage/*pharmacology
MH  - Male
MH  - Mice
MH  - Mice, Transgenic
MH  - Protein Isoforms/genetics/metabolism
MH  - RNA, Messenger/*biosynthesis
MH  - Receptor, trkB/genetics/*metabolism/physiology
MH  - Transgenes/genetics
EDAT- 2002/01/05 10:00
MHDA- 2002/05/22 10:01
CRDT- 2002/01/05 10:00
PHST- 2002/01/05 10:00 [pubmed]
PHST- 2002/05/22 10:01 [medline]
PHST- 2002/01/05 10:00 [entrez]
AID - 10.1023/a:1012775808253 [doi]
PST - ppublish
SO  - Cell Mol Neurobiol. 2001 Aug;21(4):429-35. doi: 10.1023/a:1012775808253.