PMID- 11776161
OWN - NLM
STAT- MEDLINE
DCOM- 20020124
LR  - 20061115
IS  - 0529-567X (Print)
IS  - 0529-567X (Linking)
VI  - 35
IP  - 4
DP  - 2000 Apr
TI  - [Immunotherapy by B-lymphocytes in patients with unexplained habitual abortion].
PG  - 212-3
AB  - OBJECTIVE: To investigate the safety and efficacy of immunotherapy in patients 
      with unexplained habitual abortion(UHA) with increased human leukocyte antigen 
      (HLA) mutual antigen. METHODS: Twenty-four UHA women were immunized by their 
      husband's B-lymphocytes for 3 months. RESULTS: Twenty-two of them had increased 
      HLA mutual antigen. The their anti-paternal lymphocytotoxic antitody (APCA) 
      positive rate was 8% before immunization, significantly lower than that of the 
      control group (86%). After immunization, the APCA positive rate increased 
      significantly to 75%, 20 cases achieved pregnancy and 16 deliverd normal 
      newborns. CONCLUSION: Immunotherapy by husband's B-lymphocytes is effective in 
      UHA with increased HLA mutual antigen, and may have less adverse effect.
FAU - Zhu, G
AU  - Zhu G
AD  - Dongshan District People's Hospital, Guangzhou 510080, China.
FAU - Zhou, Y
AU  - Zhou Y
FAU - Ning, B
AU  - Ning B
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Fu Chan Ke Za Zhi
JT  - Zhonghua fu chan ke za zhi
JID - 16210370R
RN  - 0 (Antilymphocyte Serum)
SB  - IM
MH  - Abortion, Habitual/immunology/*therapy
MH  - Adult
MH  - Antilymphocyte Serum/blood
MH  - B-Lymphocytes/*immunology
MH  - Female
MH  - Humans
MH  - Immunotherapy
MH  - Pregnancy
EDAT- 2002/01/05 10:00
MHDA- 2002/01/25 10:01
CRDT- 2002/01/05 10:00
PHST- 2002/01/05 10:00 [pubmed]
PHST- 2002/01/25 10:01 [medline]
PHST- 2002/01/05 10:00 [entrez]
PST - ppublish
SO  - Zhonghua Fu Chan Ke Za Zhi. 2000 Apr;35(4):212-3.