PMID- 11776593
OWN - NLM
STAT- MEDLINE
DCOM- 20020312
LR  - 20061115
IS  - 0253-3766 (Print)
IS  - 0253-3766 (Linking)
VI  - 22
IP  - 1
DP  - 2000 Jan
TI  - [Molecular cytogenetic study of bladder transitional cell carcinoma by FISH].
PG  - 36-8
AB  - OBJECTIVE: To study the molecular cytogenetic alterations of transitional cell 
      carcinoma of the urinary bladder with exfoliated cells. METHODS: Fluorescence in 
      situ hybridization (FISH) was performed using centromeric probes of chromosome 7, 
      9, 11 and 17 to examine chromosome aberration of exfoliated cells in 34 urine 
      samples and 30 bladder washings from patients with transitional cell urinary 
      bladder carcinoma. RESULTS: (1) The frequency of numerical aberration of 
      chromosome 7, 9, 11, 17 was 23.5%, 38.2%, 14.7% and 11.8% in urine and 30.0%, 
      50.0%, 26.7% and 16.7% in bladder washing, respectively. Loss of chromosome 9 was 
      the most common finding, but it was not correlated with pathological grade of 
      cancer and stage of the disease. Abnormality of chromosome 7 was however 
      associated with the clinical stage. (2) The positive rate of examination by 
      cytology and FISH was 29.4% and 55.9% in urine, 27.6% and 73.7% in bladder 
      washing, respectively. When the results of cytology and FISH were combined, the 
      positive rate increased to 67.6% and 80.0% for urine and bladder washing, 
      respectively. CONCLUSION: A number of chromosome aberrations is detected in 
      transitional cell carcinoma of the urinary bladder by FISH technique which 
      provides a basis for further understanding of its molecular pathogenesis and 
      clinical applications.
FAU - Shou, J
AU  - Shou J
AD  - Department of Urology, Cancer Hospital (Institute), Chinese Academy of Medical 
      Sciences, Peking Union Medical College, Beijing 100021, China.
FAU - Wang, M
AU  - Wang M
FAU - Ma, J
AU  - Ma J
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Zhong Liu Za Zhi
JT  - Zhonghua zhong liu za zhi [Chinese journal of oncology]
JID - 7910681
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Aneuploidy
MH  - Carcinoma, Transitional Cell/*genetics
MH  - Chromosome Aberrations
MH  - Chromosomes, Human, Pair 11
MH  - Chromosomes, Human, Pair 17
MH  - Chromosomes, Human, Pair 7
MH  - *Chromosomes, Human, Pair 9
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Male
MH  - Middle Aged
MH  - Urinary Bladder/pathology
MH  - Urinary Bladder Neoplasms/*genetics
MH  - Urine/physiology
EDAT- 2002/01/05 10:00
MHDA- 2002/03/13 10:01
CRDT- 2002/01/05 10:00
PHST- 2002/01/05 10:00 [pubmed]
PHST- 2002/03/13 10:01 [medline]
PHST- 2002/01/05 10:00 [entrez]
PST - ppublish
SO  - Zhonghua Zhong Liu Za Zhi. 2000 Jan;22(1):36-8.