PMID- 11776983
OWN - NASA
STAT- MEDLINE
DCOM- 20020712
LR  - 20061115
IS  - 1120-1797 (Print)
IS  - 1120-1797 (Linking)
VI  - 17 Suppl 1
DP  - 2001
TI  - Comparison of chromosome aberration frequencies in pre- and post-flight astronaut 
      lymphocytes irradiated in vitro with gamma rays.
PG  - 229-31
AB  - If radiosensitivity is altered in a microgravity environment, it will affect the 
      accuracy of assessing astronauts' risk from exposure to space radiation. To 
      investigate the effects of space flight on radiosensitivity, we exposed a 
      crewmember's blood to gamma rays at doses ranging from 0 to 3 Gy and analyzed 
      chromosome aberrations in mitotic lymphocytes. The blood samples were collected 
      10 days prior to an 8-day Shuttle mission, the day the flight returned, and 14 
      days after the flight. After exposure, lymphocytes were stimulated to grow in 
      media containing phytohaemagglutinin (PHA) and mitotic cells were harvested for 
      chromosome analysis using a fluorescence in situ hybridization (FISH) with whole 
      chromosome specific probes. The dose response of total exchanges showed no 
      changes in the radiosensitivity after the mission.
FAU - Wu, H
AU  - Wu H
AD  - Radiation Biophysics Laboratory, NASA Johnson Space Center, Houston, TX 77058, 
      USA.
FAU - George, K
AU  - George K
FAU - Willingham, V
AU  - Willingham V
FAU - Cucinotta, F A
AU  - Cucinotta FA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Italy
TA  - Phys Med
JT  - Physica medica : PM : an international journal devoted to the applications of 
      physics to medicine and biology : official journal of the Italian Association of 
      Biomedical Physics (AIFB)
JID - 9302888
MH  - Astronauts
MH  - *Chromosome Aberrations
MH  - Dose-Response Relationship, Radiation
MH  - *Gamma Rays
MH  - Humans
MH  - Lymphocytes/*radiation effects
MH  - Mitosis/radiation effects
MH  - Radiation Tolerance/*physiology
MH  - *Space Flight
MH  - Translocation, Genetic
MH  - *Weightlessness
OID - NASA: 00027056
OTO - NASA
OT  - NASA Center JSC
OT  - NASA Discipline Radiation Health
SFM - Flight Experiment
SFM - STS-103 Shuttle Project
SFM - manned
SFM - short duration
FIR - Cucinotta, F A
IR  - Cucinotta FA
IRAD- JSC
EDAT- 2002/01/05 10:00
MHDA- 2002/07/13 10:01
CRDT- 2002/01/05 10:00
PHST- 2002/01/05 10:00 [pubmed]
PHST- 2002/07/13 10:01 [medline]
PHST- 2002/01/05 10:00 [entrez]
PST - ppublish
SO  - Phys Med. 2001;17 Suppl 1:229-31.