PMID- 11777251
OWN - NLM
STAT- MEDLINE
DCOM- 20020607
LR  - 20071115
IS  - 1050-6586 (Print)
IS  - 1050-6586 (Linking)
VI  - 15
IP  - 6
DP  - 2001 Nov-Dec
TI  - Presence and characterization of sensitization to staphylococcal enterotoxins in 
      patients with allergic rhinitis.
PG  - 417-21
AB  - Exotoxins derived from Staphylococcus aureus appear to be involved in the 
      pathogenesis of allergic diseases, especially atopic dermatitis (AD). However, 
      little is known about sensitization to enterotoxins in cases of respiratory 
      allergies. Because the nasal cavity is a primary site of colonization by S. 
      aureus, we sought to determine the prevalence and role of serum immunoglobulin E 
      (IgE) antibodies against staphylococcal enterotoxin A (SEA) and SEB in patients 
      with allergic rhinitis (AR). The presence of SEA- and SEB-specific IgE was 
      determined in 40 patients with AR and 16 healthy control subjects. In the 
      rhinitis group, nasal symptom score, total serum IgE, sensitization to other 
      inhaled allergens and the presence of sinusitis were determined. Twenty-five 
      percent of patients with AR were sensitized to SEA/SEB whereas 6.3% of controls 
      were sensitized to the toxins. Sensitization to SEB was predominant relative to 
      SEA. There were no significant differences in the severity of nasal symptoms and 
      complications of other allergic diseases including AD and bronchial asthma, 
      between patients with or without sensitization to SEA/SEB. However, patients 
      sensitized to these toxins were likely to show increased total serum IgE and 
      polyvalent sensitization, suggesting that exposure and subsequent sensitization 
      to SEA/SEB may be involved in polyvalent sensitization.
FAU - Okano, M
AU  - Okano M
AD  - Department of Otolaryngology-Head & Neck Surgery, Okayama University Medical 
      School, Japan.
FAU - Takishita, T
AU  - Takishita T
FAU - Yamamoto, T
AU  - Yamamoto T
FAU - Hattori, H
AU  - Hattori H
FAU - Yamashita, Y
AU  - Yamashita Y
FAU - Nishioka, S
AU  - Nishioka S
FAU - Ogawa, T
AU  - Ogawa T
FAU - Nishizaki, K
AU  - Nishizaki K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Am J Rhinol
JT  - American journal of rhinology
JID - 8807268
RN  - 0 (Enterotoxins)
RN  - 37337-57-8 (enterotoxin A, Staphylococcal)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 39424-53-8 (enterotoxin B, staphylococcal)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Antibody Specificity/immunology
MH  - Child
MH  - Child, Preschool
MH  - Enterotoxins/*immunology
MH  - Eosinophilia/blood/immunology/therapy
MH  - Female
MH  - Humans
MH  - *Immunization/methods
MH  - Immunoglobulin E/blood/immunology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Rhinitis, Allergic, Perennial/blood/*immunology/*therapy
MH  - Severity of Illness Index
MH  - Sex Factors
MH  - Sinusitis/blood/immunology/therapy
MH  - Statistics as Topic
EDAT- 2002/01/05 10:00
MHDA- 2002/06/12 10:01
CRDT- 2002/01/05 10:00
PHST- 2002/01/05 10:00 [pubmed]
PHST- 2002/06/12 10:01 [medline]
PHST- 2002/01/05 10:00 [entrez]
PST - ppublish
SO  - Am J Rhinol. 2001 Nov-Dec;15(6):417-21.