PMID- 11777837
OWN - NLM
STAT- MEDLINE
DCOM- 20020228
LR  - 20190508
IS  - 1071-412X (Print)
IS  - 1098-6588 (Electronic)
IS  - 1071-412X (Linking)
VI  - 9
IP  - 1
DP  - 2002 Jan
TI  - Immunoglobulin E antileishmanial antibody response in cutaneous leishmaniasis.
PG  - 101-4
AB  - High levels of antileishmanial immunoglobulin E (IgE) antibodies are associated 
      with disease activity in visceral leishmaniasis. Herein, we report our 
      observations about the relationship between antileishmanial IgE antibodies and 
      clinical aspects of cutaneous leishmaniasis. This study was carried out with 45 
      patients (29 male and 16 female), with ages ranging from 11 to 48 years. All 
      subjects were from an area to which leishmaniasis is endemic, Corte de Pedra 
      (Bahia, Brazil), and the duration of the illness was </=30 days. The patients 
      were classified as positive or negative for IgE serology in enzyme-linked 
      immunosorbent assay with leishmanial antigens. IgE antibodies were detected in 18 
      patients (optical density, 0.421 +/- 0.30; 95% confidence interval, 0.27 to 
      0.57), and only 3 (17%) had more than one ulcer. In this group the diameter of 
      Montenegro's reaction was 18 +/- 12.2 mm. In the group with negative IgE 
      serology, 11 of 27 patients (48%) presented two or more cutaneous ulcers, and the 
      mean of the skin test result was 9 +/- 6.9 mm. There was a positive correlation 
      between IgE antibody levels and Montenegro's reaction size and an inverse 
      correlation between IgE antileishmanial antibodies and the number of skin ulcers. 
      The presence of antileishmanial IgE antibodies in cutaneous leishmaniasis may be 
      a result of immunoregulatory events with clinical implications.
FAU - Sousa-Atta, Maria L B
AU  - Sousa-Atta ML
AD  - Departamento de Analises Clinicas e Toxicologicas, Faculdade de Farmacia da 
      Universidade Federal da Bahia, 40110-160 Salvador, Bahia, Brazil.
FAU - Salame, Gregorio S
AU  - Salame GS
FAU - D'Oliveira, Argemiro Jr
AU  - D'Oliveira A Jr
FAU - Almeida, Roque P
AU  - Almeida RP
FAU - Atta, Ajax M
AU  - Atta AM
FAU - Carvalho, Edgar M
AU  - Carvalho EM
LA  - eng
GR  - AI-30639/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Clin Diagn Lab Immunol
JT  - Clinical and diagnostic laboratory immunology
JID - 9421292
RN  - 0 (Antibodies, Protozoan)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Animals
MH  - Antibodies, Protozoan/*blood
MH  - Child
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Leishmania braziliensis/*immunology
MH  - Leishmaniasis, Cutaneous/*immunology
MH  - Male
MH  - Middle Aged
PMC - PMC119873
EDAT- 2002/01/05 10:00
MHDA- 2002/03/01 10:01
PMCR- 2002/01/01
CRDT- 2002/01/05 10:00
PHST- 2002/01/05 10:00 [pubmed]
PHST- 2002/03/01 10:01 [medline]
PHST- 2002/01/05 10:00 [entrez]
PHST- 2002/01/01 00:00 [pmc-release]
AID - 0124 [pii]
AID - 10.1128/cdli.9.1.101-104.2002 [doi]
PST - ppublish
SO  - Clin Diagn Lab Immunol. 2002 Jan;9(1):101-4. doi: 10.1128/cdli.9.1.101-104.2002.