PMID- 11777841
OWN - NLM
STAT- MEDLINE
DCOM- 20020228
LR  - 20190508
IS  - 1071-412X (Print)
IS  - 1098-6588 (Electronic)
IS  - 1071-412X (Linking)
VI  - 9
IP  - 1
DP  - 2002 Jan
TI  - Stimulant-dependent modulation of cytokines and chemokines by airway epithelial 
      cells: cross talk between pulmonary epithelial and peripheral blood mononuclear 
      cells.
PG  - 126-31
AB  - Staphylococcal exotoxins (SE) and lipopolysaccharide (LPS) stimulate cells of the 
      immune system to produce proinflammatory cytokines and chemokines which mediate 
      septic shock and acute lung inflammation. A coculture of human peripheral blood 
      mononuclear cells (PBMC) and pulmonary A549 epithelial cells was used to 
      investigate inflammatory responses triggered by staphylococcal enterotoxin B 
      (SEB), toxic shock syndrome toxin 1, and LPS. The levels of interleukin 1beta 
      (IL-1beta), IL-6, gamma interferon-inducible protein 10, monocyte chemotactic 
      protein 1 (MCP-1), macrophage inflammatory protein 1alpha, and RANTES were 
      enhanced by 3.8-, 4.2-, 3.1-, 8.9-, 2-, and 2.9-fold, respectively, in cocultures 
      of SEB-stimulated cells compared to in SEB-stimulated PBMC. In LPS-stimulated 
      cocultures, only MCP-1 and RANTES levels were increased. These data suggest that 
      the modulation of specific cytokines and chemokines is dependent on the stimulus 
      and that there is bidirectional interaction between PBMC and lung epithelial 
      cells to influence the immune response to these different stimuli.
FAU - Krakauer, Teresa
AU  - Krakauer T
AD  - Department of Immunology and Molecular Biology, United States Army Medical 
      Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 
      21702-5011, USA. teresa.krakauer@det.amedd.army.mil
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Clin Diagn Lab Immunol
JT  - Clinical and diagnostic laboratory immunology
JID - 9421292
RN  - 0 (Bacterial Toxins)
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
RN  - 0 (Enterotoxins)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Superantigens)
RN  - 0 (enterotoxin F, Staphylococcal)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 39424-53-8 (enterotoxin B, staphylococcal)
SB  - IM
MH  - *Bacterial Toxins
MH  - *Cell Communication
MH  - Cell Line
MH  - Chemokines/*biosynthesis
MH  - Coculture Techniques
MH  - Cytokines/*biosynthesis
MH  - Enterotoxins/pharmacology
MH  - Epithelial Cells/immunology
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/analysis
MH  - Leukocytes, Mononuclear/*immunology
MH  - Lipopolysaccharides/pharmacology
MH  - Lung/cytology/*immunology
MH  - *Superantigens
PMC - PMC119912
EDAT- 2002/01/05 10:00
MHDA- 2002/03/01 10:01
PMCR- 2002/01/01
CRDT- 2002/01/05 10:00
PHST- 2002/01/05 10:00 [pubmed]
PHST- 2002/03/01 10:01 [medline]
PHST- 2002/01/05 10:00 [entrez]
PHST- 2002/01/01 00:00 [pmc-release]
AID - 0209 [pii]
AID - 10.1128/cdli.9.1.126-131.2002 [doi]
PST - ppublish
SO  - Clin Diagn Lab Immunol. 2002 Jan;9(1):126-31. doi: 10.1128/cdli.9.1.126-131.2002.