PMID- 11779163
OWN - NLM
STAT- MEDLINE
DCOM- 20020225
LR  - 20211203
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 290
IP  - 1
DP  - 2002 Jan 11
TI  - 5-amino-4-imidazolecarboxamide riboside confers strong tolerance to glucose 
      starvation in a 5'-AMP-activated protein kinase-dependent fashion.
PG  - 263-7
AB  - Acadesine, 5-amino-4-imidazolecarboxamide riboside (AICAR), has been claimed to 
      protect the heart, lung, and small intestine against ischemic damage. The 
      biochemical mechanisms of this effect of AICAR are not yet fully understood. To 
      understand the mechanism, we examined the effect of AICAR on glucose starvation, 
      since cellular responses to ischemia could be regarded as a protective response 
      to an insufficient blood supply, cells might display adaptive reactions not only 
      to oxygen deficiency but to nutrient deficiency. AICAR was found to confer strong 
      tolerance to glucose starvation. By using antisense RNA expression vector for 
      alpha subunit of 5'-AMP-activated protein kinase, the effect of AICAR was found 
      to be dependent on 5'-AMP-activated protein kinase containing the alpha2 subunit. 
      The AICAR effect was also dependent on the presence of amino acids, indicating an 
      energy source switch from glucose to amino acids.
CI  - (c)2002 Elsevier Science.
FAU - Hashimoto, Koichi
AU  - Hashimoto K
AD  - Investigative Treatment Division, National Cancer Center Research Institute East, 
      6-5-1, Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.
FAU - Kato, Kazuyoshi
AU  - Kato K
FAU - Imamura, Kazuhiro
AU  - Imamura K
FAU - Kishimoto, Atsuhiro
AU  - Kishimoto A
FAU - Yoshikawa, Hiroyuki
AU  - Yoshikawa H
FAU - Taketani, Yuuji
AU  - Taketani Y
FAU - Esumi, Hiroyasu
AU  - Esumi H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Multienzyme Complexes)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Oligonucleotides, Antisense)
RN  - 0 (RNA, Antisense)
RN  - 0 (Ribonucleotides)
RN  - 0 (Transcription Factors)
RN  - 360-97-4 (Aminoimidazole Carboxamide)
RN  - 63231-63-0 (RNA)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - EC 2.7.11.1 (PRKAA2 protein, human)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.31 (AMP-Activated Protein Kinases)
RN  - F0X88YW0YK (AICA ribonucleotide)
RN  - IY9XDZ35W2 (Glucose)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - AMP-Activated Protein Kinases
MH  - Adenosine Triphosphate/metabolism
MH  - Aminoimidazole Carboxamide/*analogs & derivatives/*metabolism
MH  - Blotting, Northern
MH  - Cell Line
MH  - Cell Survival
MH  - DNA-Binding Proteins/biosynthesis
MH  - Fibroblasts/metabolism
MH  - Glucose/*metabolism
MH  - Humans
MH  - Hypoglycemic Agents/*pharmacology
MH  - Hypoxia
MH  - Hypoxia-Inducible Factor 1
MH  - Hypoxia-Inducible Factor 1, alpha Subunit
MH  - Multienzyme Complexes/*metabolism
MH  - Nuclear Proteins/biosynthesis
MH  - Oligonucleotides, Antisense/pharmacology
MH  - Oxygen/metabolism
MH  - Protein Serine-Threonine Kinases/*metabolism
MH  - RNA/metabolism
MH  - RNA, Antisense/metabolism
MH  - Ribonucleotides/*metabolism
MH  - Time Factors
MH  - *Transcription Factors
MH  - Tumor Cells, Cultured
EDAT- 2002/01/10 10:00
MHDA- 2002/02/28 10:01
CRDT- 2002/01/10 10:00
PHST- 2002/01/10 10:00 [pubmed]
PHST- 2002/02/28 10:01 [medline]
PHST- 2002/01/10 10:00 [entrez]
AID - S0006291X01961935 [pii]
AID - 10.1006/bbrc.2001.6193 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2002 Jan 11;290(1):263-7. doi: 
      10.1006/bbrc.2001.6193.