PMID- 11779758
OWN - NLM
STAT- MEDLINE
DCOM- 20020117
LR  - 20211203
IS  - 0003-4967 (Print)
IS  - 1468-2060 (Electronic)
IS  - 0003-4967 (Linking)
VI  - 61
IP  - 1
DP  - 2002 Jan
TI  - Heat shock protein 70 gene polymorphisms in Mexican patients with 
      spondyloarthropathies.
PG  - 48-51
AB  - OBJECTIVE: To investigate the role of HSP70 genes as contributors to genetic 
      susceptibility of the spondyloarthropathies (SpA) in the Mexican population. 
      METHODS: The study included 150 patients with SpA (undifferentiated 
      spondyloarthropathy (uSpA) 68, ankylosing spondylitis (AS) 60, and reactive 
      arthritis 22) and 158 healthy controls. HSP70-1, HSP70-2 and HSP70-hom genotypes 
      were analysed by the polymerase chain reaction-restriction fragment length 
      polymorphism technique. Statistical methods included the Mantel-Haenzel, chi(2), 
      Fisher's exact test, and Woolf's method for odds ratio (OR). RESULTS: HSP70-2 B/B 
      genotype frequency was increased in the whole group of patients with SpA 
      (pC<0.05, OR=4.3), as well as in the different clinical subgroups (pC<0.05, 
      OR=4.2 for AS; pC<0.05, OR=4.4 for uSpA; and pC<0.05, OR=4.1 for ReA). This 
      frequency remained significantly increased when the patients with B27 negative 
      SpA were analysed. On the other hand, HSP70-hom locus analysis showed 
      significantly increased frequency of A allele in the whole group of SpA (pC<0.05, 
      OR=3.4), as well as in the groups with AS (pC<0.05, OR=5.6) and with uSpA 
      (pC<0.05, OR=3.1), when compared with healthy controls. In this case, also, the 
      genotype A/A was increased in the whole group of SpA (pC<0.05, OR=4.5), as well 
      as in patients with AS (pC<0.05, OR=6.4) and with uSpA (pC<0.05, OR=3.7). When 
      the patients with B27 negative SpA were analysed the frequencies of HSP70-hom A 
      allele and A/A genotype remained significantly increased in the whole group of 
      SpA (pC<0.05, OR=3.2 for the A allele and pC<0.05, OR=4.2 for the A/A genotype) 
      and in the uSpA subgroup (pC<0.05, OR=3.8 for the A allele and pC<0.05, OR=4.3 
      for the A/A genotype). CONCLUSION: In addition to the association of SpA with 
      HLA-B27, there is a significant association of HSP70-2 and HSP70-hom alleles with 
      SpA in Mexicans. This association seems to be independent of the susceptibility 
      conferred by HLA-B27 in the group of patients with uSpA.
FAU - Vargas-Alarcon, G
AU  - Vargas-Alarcon G
AD  - Cellular Biology Section, Department of Physiology, Instituto Nacional de 
      Cardiologia Ignacio Chavez, Tlalpan, Mexico DF, Mexico. gvargas63@yahoo.com
FAU - Londono, J D
AU  - Londono JD
FAU - Hernandez-Pacheco, G
AU  - Hernandez-Pacheco G
FAU - Gamboa, R
AU  - Gamboa R
FAU - Castillo, E
AU  - Castillo E
FAU - Pacheco-Tena, C
AU  - Pacheco-Tena C
FAU - Cardiel, M H
AU  - Cardiel MH
FAU - Granados, J
AU  - Granados J
FAU - Burgos-Vargas, R
AU  - Burgos-Vargas R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Ann Rheum Dis
JT  - Annals of the rheumatic diseases
JID - 0372355
RN  - 0 (HSP70 Heat-Shock Proteins)
RN  - 0 (PHB2 protein, human)
RN  - 0 (Prohibitins)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Case-Control Studies
MH  - Confidence Intervals
MH  - Female
MH  - Genotype
MH  - HSP70 Heat-Shock Proteins/*genetics
MH  - Humans
MH  - Male
MH  - Mexico
MH  - Odds Ratio
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Restriction Fragment Length
MH  - Prohibitins
MH  - Spondylarthropathies/*genetics
PMC - PMC1753895
EDAT- 2002/01/10 10:00
MHDA- 2002/01/23 10:01
PMCR- 2005/01/01
CRDT- 2002/01/10 10:00
PHST- 2002/01/10 10:00 [pubmed]
PHST- 2002/01/23 10:01 [medline]
PHST- 2002/01/10 10:00 [entrez]
PHST- 2005/01/01 00:00 [pmc-release]
AID - 10.1136/ard.61.1.48 [doi]
PST - ppublish
SO  - Ann Rheum Dis. 2002 Jan;61(1):48-51. doi: 10.1136/ard.61.1.48.