PMID- 11779968
OWN - NLM
STAT- MEDLINE
DCOM- 20020222
LR  - 20191105
IS  - 0736-0258 (Print)
IS  - 0736-0258 (Linking)
VI  - 18
IP  - 6
DP  - 2001 Nov
TI  - Analogous corticocortical inhibition and facilitation in ipsilateral and 
      contralateral human motor cortex representations of the tongue.
PG  - 550-8
AB  - How the human brain controls activation of the ipsilateral part of midline 
      muscles is unknown. We studied corticospinal and corticocortical network 
      excitability of both ipsilateral and contralateral motor representations of the 
      tongue to determine whether they are under analogous or disparate inhibitory and 
      facilitatory corticocortical control. Motor evoked potentials (MEPs) to 
      unilateral focal transcranial magnetic stimulation (TMS) of the tongue primary 
      motor cortex were recorded simultaneously from the ipsilateral and contralateral 
      lingual muscles. Single-pulse TMS was used to assess motor threshold (MT) and MEP 
      recruitment. Paired-pulse TMS was used to study intracortical inhibition (ICI) 
      and intracortical facilitation (ICF) at various interstimulus intervals (ISIs) 
      between the conditioning stimulus (CS) and the test stimulus (TS), and at 
      different CS and TS intensities, respectively. Focal TMS invariably produced MEPs 
      in both ipsilateral and contralateral lingual muscles. MT was lower and MEP 
      recruitment was steeper when recorded from the contralateral muscle group. ICI 
      and ICF were identical in the ipsilateral and contralateral representations, with 
      inhibition occurring at short ISIs (2 and 3 ms) and facilitation occurring at 
      longer ISIs (10 and 15 ms). Moreover, changing one stimulus parameter regularly 
      produced analogous changes in MEP size bilaterally, revealing strong linear 
      correlations between ipsilateral and contralateral ICI and ICF (P < 0.0001). 
      These findings indicate that the ipsilateral and contralateral representations of 
      the tongue are under analogous inhibitory and facilitatory control, possibly by a 
      common intracortical network.
FAU - Muellbacher, W
AU  - Muellbacher W
AD  - Human Motor Control Section, National Institute of Neurological Disorders and 
      Stroke, National Institutes of Health, Bethesda, Maryland 20892-1428, USA.
FAU - Boroojerdi, B
AU  - Boroojerdi B
FAU - Ziemann, U
AU  - Ziemann U
FAU - Hallett, M
AU  - Hallett M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Neurophysiol
JT  - Journal of clinical neurophysiology : official publication of the American 
      Electroencephalographic Society
JID - 8506708
SB  - IM
MH  - Adult
MH  - Dominance, Cerebral/*physiology
MH  - Electric Stimulation
MH  - Electromyography
MH  - Evoked Potentials, Motor/physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Motor Cortex/*physiopathology
MH  - Motor Neurons/physiology
MH  - Neural Inhibition/*physiology
MH  - Reference Values
MH  - Synaptic Transmission/*physiology
MH  - Tongue/*innervation
EDAT- 2002/01/10 10:00
MHDA- 2002/02/23 10:01
CRDT- 2002/01/10 10:00
PHST- 2002/01/10 10:00 [pubmed]
PHST- 2002/02/23 10:01 [medline]
PHST- 2002/01/10 10:00 [entrez]
AID - 10.1097/00004691-200111000-00005 [doi]
PST - ppublish
SO  - J Clin Neurophysiol. 2001 Nov;18(6):550-8. doi: 10.1097/00004691-200111000-00005.