PMID- 11780340
OWN - NLM
STAT- MEDLINE
DCOM- 20020221
LR  - 20061115
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 114
IP  - 7
DP  - 2001 Jul
TI  - Mechanisms of multiple organ damages in acute necrotizing pancreatitis.
PG  - 738-42
AB  - OBJECTIVE: To determine the role of systemic inflammatory response syndrome 
      (SIRS) and multiple organ dysfunction syndrome (MODS), and evaluate the progress 
      from SIRS to MODS and the therapeutic strategies for acute necrotizing 
      pancreatitis (ANP). METHODS: Rat ANP models were made by retrograde injection of 
      3.5% sodium taurocholate 2.5 ml/kg into the pancreatic duct. Serum interleukin-8 
      (IL-8), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-alpha 
      (TNF alpha), amylase, endotoxin, and albumin were examined. The morphology and 
      pathology of the pancreas, liver, lung, kidney and heart after ANP were observed. 
      Finally, TNF alpha mRNA in the liver, lung, kidney and heart after ANP were 
      observed by reverse transcriptase-polymerase chain reactions, and the efficiency 
      of somatostatin and growth hormone were also observed in this experiment. 
      RESULTS: ANP led to remarkable elevation of the inflammatory mediators which were 
      positively correlated with the development of ANP and MODS. Somatostatin and 
      growth hormone inhibited inflammatory mediators and TNF alpha mRNA 
      overexpressions, reduced the risk of MODS, corrected hypoalbuminemia, reversed 
      negative nitrogen balance, and controlled the reduction of cell groups with 
      functions and reasonably intervened SIRS caused by ANP. CONCLUSION: TNF alpha 
      mRNA plays an important role in ANP progression. The amelioration of ANP by 
      combination treatment with somatostatin and growth hormone leads to the reduction 
      of complications and marked increase in survival.
FAU - Zhang, Q
AU  - Zhang Q
AD  - Department of Surgery, Huashan Hospital, Shanghai Medical University, Shanghai 
      200040, China. qunhuazh@sh163a.sta.net.cn
FAU - Ni, Q
AU  - Ni Q
FAU - Cai, D
AU  - Cai D
FAU - Zhang, Y
AU  - Zhang Y
FAU - Zhang, N
AU  - Zhang N
FAU - Hou, L
AU  - Hou L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Male
MH  - Multiple Organ Failure/*etiology
MH  - Pancreatitis, Acute Necrotizing/*complications/mortality/pathology
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Survival Rate
MH  - Systemic Inflammatory Response Syndrome/etiology
MH  - Tumor Necrosis Factor-alpha/genetics
EDAT- 2002/01/10 10:00
MHDA- 2002/02/22 10:01
CRDT- 2002/01/10 10:00
PHST- 2002/01/10 10:00 [pubmed]
PHST- 2002/02/22 10:01 [medline]
PHST- 2002/01/10 10:00 [entrez]
PST - ppublish
SO  - Chin Med J (Engl). 2001 Jul;114(7):738-42.