PMID- 11780418
OWN - NLM
STAT- MEDLINE
DCOM- 20020221
LR  - 20061115
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 114
IP  - 5
DP  - 2001 May
TI  - Relationship between c-fos gene expression and delayed neuronal death in rat 
      neonatal hippocampus following hypoxic-ischemic insult.
PG  - 520-3
AB  - OBJECTIVE: To explore the mechanism of perinatal hypoxia-ischemia encephalopathy, 
      we studied the expression of the c-fos gene and its relationship with delayed 
      neuronal death in a rat model. METHODS: Cerebral hypoxia-ischemia was produced in 
      7-day-old SD rats using the Rice model. Reverse transcription PCR (RT-PCR), 
      immunohistochemistry and terminal deoxynucleotidyl transferase-mediated dUTP nick 
      end labeling (TUNEL) were used to detect the expression of c-fos gene and cell 
      apoptosis in the hippocampus. RESULTS: The selective expression of c-fos and 
      delayed cell apoptosis were observed in the hypoxia-ischemia hippocampus. 
      Expression of the c-fos gene was seen in the CA4 and cingulate sulcus neurons, 
      and apoptosis was observed in the CA1 neurons. CONCLUSION: Transient expression 
      of the c-fos gene may induce cerebral cell apoptosis, and may have complex 
      relations with delayed cell death.
FAU - Jiang, L
AU  - Jiang L
AD  - Department of Pediatrics, Affiliated Hospital, Nanjing Railway Medical College, 
      Nanjing 210009, China.
FAU - Ding, Y
AU  - Ding Y
FAU - Tang, Y
AU  - Tang Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - *Apoptosis
MH  - Brain Ischemia/metabolism/*pathology
MH  - *Genes, fos
MH  - Hippocampus/metabolism/*pathology
MH  - Immunohistochemistry
MH  - Proto-Oncogene Proteins c-fos/analysis
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2002/01/10 10:00
MHDA- 2002/02/22 10:01
CRDT- 2002/01/10 10:00
PHST- 2002/01/10 10:00 [pubmed]
PHST- 2002/02/22 10:01 [medline]
PHST- 2002/01/10 10:00 [entrez]
PST - ppublish
SO  - Chin Med J (Engl). 2001 May;114(5):520-3.