PMID- 11780465
OWN - NLM
STAT- MEDLINE
DCOM- 20020221
LR  - 20111117
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 114
IP  - 4
DP  - 2001 Apr
TI  - Relationship between HLA-DRB1 and DQ alleles and the genetic susceptibility to 
      type 1 diabetes.
PG  - 407-9
AB  - OBJECTIVE: To study the relationship between human leukocyte antigen (HLA)-DRB1 
      and DQ alleles and the genetic susceptibility of type 1 diabetes in North Chinese 
      children. METHODS: Polymerase chain reaction (PCR) techniques were used to 
      amplify the second exon of DRB1 and DQ alleles, after which sequence specific 
      olignucleotide probe (SSOP) dot blot hybridization techniques were used to 
      analyze the amplified products. RESULTS: DRB1 * 0301, DQA1 * 0301, DQB1 * 0201 
      alleles and DRB1 * 0301-DQA1 * 0501-DQB1 * 0201 haplotype were significantly 
      increased in patients, while DQA1 * 0103 and DQB1 * 0601 alleles were 
      significantly increased in controls. The distribution of DR4 and DR9 haplotypes 
      in patients and controls were not significantly different, but DR3/DR4 and 
      DR4/DR9 heterozygotes were significantly increased in patients. CONCLUSIONS: DRB1 
      * 0301, DQA1 * 0301 and DQB1 * 0201 confer susceptibility while DQA1 * 0103 and 
      DQB1 * 0601 confer protection to type 1 diabetes. DRB1 * 0301-DQA1 * 0501-DQB1 * 
      0201 haplotype offers a predisposition to type 1 diabetes in North Chinese. 
      Although the distribution of DR4 and DR9 in patients and controls had no 
      significant difference, DR3/DR4 and DR3/DR9 heterozygotes were significantly 
      increased in patients, showing that the susceptive effects of DR3 and DR4 or DR4 
      and DR9 haplotypes could be added up.
FAU - Sang, Y
AU  - Sang Y
AD  - Department of Endocrinology, Beijing Children's Hospital, Capital University of 
      Medical Sciences, Beijing 100045, China.
FAU - Yan, C
AU  - Yan C
FAU - Zhu, C
AU  - Zhu C
FAU - Ni, G
AU  - Ni G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*03:01 antigen)
SB  - IM
MH  - *Alleles
MH  - Child
MH  - Diabetes Mellitus, Type 1/*genetics
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Humans
EDAT- 2002/01/10 10:00
MHDA- 2002/02/22 10:01
CRDT- 2002/01/10 10:00
PHST- 2002/01/10 10:00 [pubmed]
PHST- 2002/02/22 10:01 [medline]
PHST- 2002/01/10 10:00 [entrez]
PST - ppublish
SO  - Chin Med J (Engl). 2001 Apr;114(4):407-9.