PMID- 1178108
OWN - NLM
STAT- MEDLINE
DCOM- 19760102
LR  - 20031114
IS  - 0300-8819 (Print)
IS  - 0300-8819 (Linking)
VI  - 5
IP  - 4
DP  - 1975 Aug
TI  - Sialoglycoprotein synthesis in developing rat brain.
PG  - 221-7
AB  - The postnatal developmental profiles of the protein-bound sialic acid content and 
      the activities of CMP-N-acetylneuraminic acid (CMP-AcNeu) synthetase (EC 
      2.7.7.43) and glycoprotein sialyltransferase, enzymes involved in 
      sialoglycoprotein biosynthesis, were estimated in the rat brain. The 
      sialoglycoprotein level appeared to increase 2-fold from birth to about 20 days 
      of age, which correlates with the outgrowth of the cell processes in this period. 
      In contrast, the activities per g wet tissue of the enzymes were highest at birth 
      and showed decreasing tendencies during maturation. This revealed that, at least 
      at a certain stage during development, the sialyltransferase is present in 
      structures other than synaptic membranes, since the new-born rat brain is devoid 
      of these membranes. The developmental profile of the endogenous, sialic acid 
      accepting molecules was very similar to that of the sialoglycoproteins. It was 
      concluded that cerebral sialoglycoprotein biosynthesis during postnatal 
      development is not limited by the activities of the synthetase and the 
      transferase, but may largely depend on the production of the endogenous 
      acceptors, which are presumed to be the natural precursors for the 
      sialoglycoproteins.
FAU - van den Eijnden, D H
AU  - van den Eijnden DH
FAU - van Dijk, W
AU  - van Dijk W
FAU - Roukema, P A
AU  - Roukema PA
LA  - eng
PT  - Journal Article
PL  - England
TA  - Neurobiology
JT  - Neurobiology
JID - 7610562
RN  - 0 (Glycoproteins)
RN  - 0 (Sialic Acids)
RN  - EC 2.4.99.- (Sialyltransferases)
RN  - EC 2.7.7.43 (N-Acylneuraminate Cytidylyltransferase)
SB  - IM
MH  - Animals
MH  - Brain/enzymology/growth & development/*metabolism
MH  - Female
MH  - Glycoproteins/*biosynthesis
MH  - Male
MH  - N-Acylneuraminate Cytidylyltransferase/metabolism
MH  - Rats
MH  - Sialic Acids/*biosynthesis
MH  - Sialyltransferases/metabolism
MH  - Time Factors
EDAT- 1975/08/01 00:00
MHDA- 1975/08/01 00:01
CRDT- 1975/08/01 00:00
PHST- 1975/08/01 00:00 [pubmed]
PHST- 1975/08/01 00:01 [medline]
PHST- 1975/08/01 00:00 [entrez]
PST - ppublish
SO  - Neurobiology. 1975 Aug;5(4):221-7.