PMID- 11782652
OWN - NLM
STAT- MEDLINE
DCOM- 20020219
LR  - 20190901
IS  - 0195-9131 (Print)
IS  - 0195-9131 (Linking)
VI  - 34
IP  - 1
DP  - 2002 Jan
TI  - Adaptations to short-term high-fat diet persist during exercise despite high 
      carbohydrate availability.
PG  - 83-91
AB  - PURPOSE: Five days of a high-fat diet produce metabolic adaptations that increase 
      the rate of fat oxidation during prolonged exercise. We investigated whether 
      enhanced rates of fat oxidation during submaximal exercise after 5 d of a 
      high-fat diet would persist in the face of increased carbohydrate (CHO) 
      availability before and during exercise. METHODS: Eight well-trained subjects 
      consumed either a high-CHO (9.3 g x kg(-1) x d(-1) CHO, 1.1 g x kg(-1) x d(-1) 
      fat; HCHO) or an isoenergetic high-fat diet (2.5 g x kg(-1) x d(-1) CHO, 4.3 g x 
      kg(-1) x d(-1) fat; FAT-adapt) for 5 d followed by a high-CHO diet and rest on 
      day 6. On day 7, performance testing (2 h steady-state (SS) cycling at 70% peak 
      O(2) uptake [VO(2peak)] + time trial [TT]) of 7 kJ x kg(-1)) was undertaken after 
      a CHO breakfast (CHO 2 g x kg(-1)) and intake of CHO during cycling (0.8 g x 
      kg(-1) x h(-1)). RESULTS: FAT-adapt reduced respiratory exchange ratio (RER) 
      values before and during cycling at 70% VO(2peak); RER was restored by 1 d CHO 
      and CHO intake during cycling (0.90 +/- 0.01, 0.80 +/- 0.01, 0.91 +/- 0.01, for 
      days 1, 6, and 7, respectively). RER values were higher with HCHO (0.90 +/- 0.01, 
      0.88 +/- 0.01 (HCHO > FAT-adapt, P < 0.05), 0.95 +/- 0.01 (HCHO > FAT-adapt, P < 
      0.05)). On day 7, fat oxidation remained elevated (73 +/- 4 g vs 45 +/- 3 g, P < 
      0.05), whereas CHO oxidation was reduced (354 +/- 11 g vs 419 +/- 13 g, P < 0.05) 
      throughout SS in FAT-adapt versus HCHO. TT performance was similar for both 
      trials (25.53 +/- 0.67 min vs 25.45 +/- 0.96 min, NS). CONCLUSION: Adaptations to 
      a short-term high-fat diet persisted in the face of high CHO availability before 
      and during exercise, but failed to confer a performance advantage during a TT 
      lasting approximately 25 min undertaken after 2 h of submaximal cycling.
FAU - Burke, Louise M
AU  - Burke LM
AD  - Sports Science and Sports Medicine, Australian Institute of Sport, Belconnen 
      2616, Australia. louise.burke@ausport.gov.au
FAU - Hawley, John A
AU  - Hawley JA
FAU - Angus, Damien J
AU  - Angus DJ
FAU - Cox, Gregory R
AU  - Cox GR
FAU - Clark, Sally A
AU  - Clark SA
FAU - Cummings, Nicola K
AU  - Cummings NK
FAU - Desbrow, Ben
AU  - Desbrow B
FAU - Hargreaves, Mark
AU  - Hargreaves M
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Med Sci Sports Exerc
JT  - Medicine and science in sports and exercise
JID - 8005433
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Insulin)
RN  - 33X04XA5AT (Lactic Acid)
RN  - PDC6A3C0OX (Glycerol)
SB  - IM
MH  - Adaptation, Physiological/*physiology
MH  - Adult
MH  - Bicycling/*physiology
MH  - Blood Glucose/analysis
MH  - Cross-Over Studies
MH  - Dietary Carbohydrates/*metabolism
MH  - Dietary Fats/*metabolism
MH  - Double-Blind Method
MH  - Exercise/*physiology
MH  - Fasting/metabolism
MH  - Fatty Acids, Nonesterified/blood
MH  - Glycerol/blood
MH  - Humans
MH  - Insulin/blood
MH  - Lactic Acid/blood
MH  - Male
MH  - Oxidation-Reduction
MH  - Oxygen Consumption/physiology
MH  - Physical Endurance/physiology
MH  - Task Performance and Analysis
EDAT- 2002/01/10 10:00
MHDA- 2002/02/20 10:01
CRDT- 2002/01/10 10:00
PHST- 2002/01/10 10:00 [pubmed]
PHST- 2002/02/20 10:01 [medline]
PHST- 2002/01/10 10:00 [entrez]
AID - 10.1097/00005768-200201000-00014 [doi]
PST - ppublish
SO  - Med Sci Sports Exerc. 2002 Jan;34(1):83-91. doi: 
      10.1097/00005768-200201000-00014.