PMID- 11783117
OWN - NLM
STAT- MEDLINE
DCOM- 20020301
LR  - 20061115
IS  - 0253-3766 (Print)
IS  - 0253-3766 (Linking)
VI  - 23
IP  - 4
DP  - 2001 Jul
TI  - [Correlation between cell-functional differentiation phenotype and 
      pathobiological behavior of gastric carcinoma].
PG  - 320-2
AB  - OBJECTIVE: To demonstrate the correlation between cell-functional differentiation 
      features and invasion, metastasis of gastric carcinoma (GC) by establishing a new 
      classification based on cell-functional differentiation. METHODS: According to 
      the direction and condition of cell-functional differentiation, 361 gastric 
      carcinomas were divided into five types to show their respective pathobiological 
      behavior. RESULTS: (1) Absorptive functional differentiation type (AFDT): 
      22.7%(82). 13.6% of the male patients developed liver metastasis, (2) 
      Mucin-secreting functional differentiation type (MSFDT): 15%(54). 98.1% of GC 
      showed serosa invasion, (3) Absorptive and mucin-producing double functional 
      differentiation type (AMPFDT): 49.9% (180). Women infliction (34.4%) and estrogen 
      receptor (ER) expression (71.7%) in this group were more common than in the other 
      types (P < 0.01). 19.4% of these female patients were complicated with ovarian 
      metastasis, (4) Specific functional differentiation type (SFDT): 3.6%(13). 69.2% 
      of these tumors derived from (high) A (amine content) + (high) P (precursor) U 
      (uptake from the ambient medium) + (presence of) D (decarboxylase) (APUD) system 
      and (5) non-functional differentiation type (NFDT): 8.9%(32). 59.4% developed 
      lymphatic metastasis. The 5-year survival rates of these types were 58.5%, 28.6%, 
      24.7%, 60.0% and 28.1%, respectively. CONCLUSION: This new cell-functional 
      classification of gastric cancer is helpful by indicating their pathobiological 
      behavior and characteristics of invasion and metastasis. Further study is needed 
      to clarify the correlation between cell-functional differentiation phenotypes and 
      their relevant genotypes as well as the inherent relationship between the 
      biological behavior.
FAU - Xin, Y
AU  - Xin Y
AD  - Fourth Laboratory, Cancer Institute, China Medical University, Shenyang 110001, 
      China.
FAU - Li, X
AU  - Li X
FAU - Wang, Y
AU  - Wang Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Zhong Liu Za Zhi
JT  - Zhonghua zhong liu za zhi [Chinese journal of oncology]
JID - 7910681
RN  - 0 (Mucins)
RN  - 0 (Receptors, Estrogen)
SB  - IM
MH  - *Cell Differentiation
MH  - Female
MH  - Humans
MH  - Liver Neoplasms/secondary
MH  - Lymphatic Metastasis
MH  - Male
MH  - Mucins/metabolism
MH  - Neoplasm Invasiveness
MH  - Ovarian Neoplasms/secondary
MH  - Receptors, Estrogen/metabolism
MH  - Stomach Neoplasms/metabolism/mortality/*pathology
MH  - Survival Analysis
MH  - Survival Rate
EDAT- 2002/01/11 10:00
MHDA- 2002/03/02 10:01
CRDT- 2002/01/11 10:00
PHST- 2002/01/11 10:00 [pubmed]
PHST- 2002/03/02 10:01 [medline]
PHST- 2002/01/11 10:00 [entrez]
PST - ppublish
SO  - Zhonghua Zhong Liu Za Zhi. 2001 Jul;23(4):320-2.