PMID- 11783390
OWN - NLM
STAT- MEDLINE
DCOM- 20020117
LR  - 20061115
IS  - 0529-567X (Print)
IS  - 0529-567X (Linking)
VI  - 36
IP  - 3
DP  - 2001 Mar
TI  - [Study on polymorphism of human leukocyte antigen I in patients with 
      endometriosis].
PG  - 150-2
AB  - OBJECTIVE: To study the possibility of a correlation between polymorphism of 
      human leukocyte antigen (HLA)-I antigen and occurrence of endometriosis (Em). 
      METHODS: Polymorphism of HLA-I A and B locations were detected by 
      mini-lymphocytotoxin test in 40 surgically proven Em patients and 50 normal 
      controls. The frequency of different antigens on both A and B sites were compared 
      between the 2 groups. RESULTS: No significant difference of the antigen frequency 
      at HLA-I A site was shown between Em and control groups. However, at HLA-I B 
      site, frequency of B46 antigen in Em group was significantly higher [33% Vs 16%, 
      P < 0.05, relative risk (RR) 2.5278] and frequency of B48 antigen in Em group was 
      significantly lower (3% Vs 16% P < 0.05, RR 0.1346) as compared with those of the 
      controls. CONCLUSIONS: The occurrence of Em may be associated with the presence 
      of HLA-I B46 antigen. On the contrary, the HLA-I B48 antigen might play a 
      protective role against Em.
FAU - Wang, X
AU  - Wang X
AD  - Department of Obstetrics and Gynecology, Second Affiliated Hospital, Hunan 
      Medical University, Changsha 410011, China.
FAU - Lin, Q
AU  - Lin Q
FAU - Guo, S
AU  - Guo S
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Fu Chan Ke Za Zhi
JT  - Zhonghua fu chan ke za zhi
JID - 16210370R
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Endometriosis/genetics/*immunology
MH  - Female
MH  - Genes, MHC Class I
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Middle Aged
MH  - Polymorphism, Genetic
EDAT- 2002/01/11 10:00
MHDA- 2002/01/23 10:01
CRDT- 2002/01/11 10:00
PHST- 2002/01/11 10:00 [pubmed]
PHST- 2002/01/23 10:01 [medline]
PHST- 2002/01/11 10:00 [entrez]
PST - ppublish
SO  - Zhonghua Fu Chan Ke Za Zhi. 2001 Mar;36(3):150-2.