PMID- 11787036
OWN - NLM
STAT- MEDLINE
DCOM- 20020412
LR  - 20190906
IS  - 0197-3851 (Print)
IS  - 0197-3851 (Linking)
VI  - 21
IP  - 13
DP  - 2001 Dec
TI  - Multicolour spectral karyotyping for complex chromosomal rearrangements in 
      repeated abortion or congenital anomalies.
PG  - 1123-8
AB  - Advances in molecular cytogenetics, especially the technique of fluorescence in 
      situ hybridization (FISH), have allowed more precise definition of chromosomal 
      structures, which are difficult to identify using conventional G-banding. 
      Recently, a novel approach based on hybridization of 24 fluorescent-labelled 
      chromosome painting probes was developed, termed spectral karyotyping (SKY), 
      which allows the simultaneous and differential colour display of all human 
      chromosomes. We have used SKY to identify not only five parental complex 
      translocation carriers but also minute chromosome rearrangements in the fetus. 
      Here, we concentrate attention on the clinical application of SKY for prenatal 
      diagnosis.
CI  - Copyright 2001 John Wiley & Sons, Ltd.
FAU - Tanemura, M
AU  - Tanemura M
AD  - Department of Obstetrics and Gynaecology, Nagoya City University Medical School, 
      Nagoya, Japan.
FAU - Suzumori, K
AU  - Suzumori K
FAU - Nishikawa, N
AU  - Nishikawa N
FAU - Ishihara, Y
AU  - Ishihara Y
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Prenat Diagn
JT  - Prenatal diagnosis
JID - 8106540
SB  - IM
MH  - Abortion, Habitual/*genetics
MH  - Adult
MH  - *Chromosome Aberrations
MH  - Chromosome Banding
MH  - Chromosome Painting/*methods
MH  - Congenital Abnormalities/*genetics
MH  - Female
MH  - Gene Duplication
MH  - Humans
MH  - Karyotyping/*methods
MH  - Pregnancy
MH  - Translocation, Genetic
MH  - Trisomy
EDAT- 2002/01/12 10:00
MHDA- 2002/04/16 10:01
CRDT- 2002/01/12 10:00
PHST- 2002/01/12 10:00 [pubmed]
PHST- 2002/04/16 10:01 [medline]
PHST- 2002/01/12 10:00 [entrez]
AID - 10.1002/pd.183 [pii]
AID - 10.1002/pd.183 [doi]
PST - ppublish
SO  - Prenat Diagn. 2001 Dec;21(13):1123-8. doi: 10.1002/pd.183.