PMID- 11787766
OWN - NLM
STAT- MEDLINE
DCOM- 20020924
LR  - 20131121
IS  - 0867-5910 (Print)
IS  - 0867-5910 (Linking)
VI  - 52
IP  - 4 Pt 1
DP  - 2001 Dec
TI  - Central nervous stimuli increase duodenal bicarbonate secretion by release of 
      mucosal melatonin.
PG  - 671-8
AB  - A number of common diseases in humans, including gastroduodenal ulcer and 
      irritable bowel syndrome, show circadian rhythms in pain and discomfort. The 
      neurohormone melatonin is released from enterochromaffin cells in the intestinal 
      mucosa and from the pineal gland but its role in gastrointestinal function is 
      largely unknown. We have studied the involvement of melatonin in stimulation of 
      the mucosa-protective alkaline secretion by the duodenal mucosa. A 12-mm segment 
      of proximal duodenum with an intact blood supply was cannulated in situ in 
      anesthetized rats and duodenal HCO3- secretion titrated by pH-stat. Duodenal 
      close intra-arterial infusion of melatonin or the full agonist 2-iodo-N-butanoyl- 
      5-methoxytryptamine significantly increased the secretion and pretreatment with 
      the melatonin (predominantly MT2-receptor specific) antagonist luzindole almost 
      abolished the response. Intracerebroventricular (i.c.v.) infusion of the 
      alpha1-adrenoceptor agonist phenylephrine (12.2 micromol kg(-1) x h(-1)) caused 
      an up to fivefold increased in the alkaline secretion and the melatonin 
      antagonist luzindole or cutting all peri-carotid nerves abolished the duodenal 
      secretory response to i.c.v. phenylephrine. Peripheral melatonin thus stimulates 
      duodenal mucosal HCO3- secretion and endogenous melatonin, very likely released 
      from mucosal enterochromaffin cells, is involved in mediating neural stimulation 
      of the secretion.
FAU - Sjoblom, M
AU  - Sjoblom M
AD  - Department of Physiology, Uppsala University, Sweden.
FAU - Flemstrom, G
AU  - Flemstrom G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - J Physiol Pharmacol
JT  - Journal of physiology and pharmacology : an official journal of the Polish 
      Physiological Society
JID - 9114501
RN  - 0 (Bicarbonates)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Receptors, Melatonin)
RN  - JL5DK93RCL (Melatonin)
SB  - IM
MH  - Animals
MH  - Bicarbonates/*metabolism
MH  - Brain/drug effects/*physiology
MH  - Duodenum/*drug effects/metabolism
MH  - Injections, Intraventricular
MH  - Male
MH  - Melatonin/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Cell Surface/physiology
MH  - Receptors, Cytoplasmic and Nuclear/physiology
MH  - Receptors, Melatonin
EDAT- 2002/01/15 10:00
MHDA- 2002/09/25 06:00
CRDT- 2002/01/15 10:00
PHST- 2002/01/15 10:00 [pubmed]
PHST- 2002/09/25 06:00 [medline]
PHST- 2002/01/15 10:00 [entrez]
PST - ppublish
SO  - J Physiol Pharmacol. 2001 Dec;52(4 Pt 1):671-8.