PMID- 11787953
OWN - NLM
STAT- MEDLINE
DCOM- 20020701
LR  - 20131121
IS  - 1230-6002 (Print)
IS  - 1230-6002 (Linking)
VI  - 53
IP  - 2
DP  - 2001 Mar-Apr
TI  - Effect of intraportal verapamil infusion on hepatic ischemia-reperfusion injury.
PG  - 137-41
AB  - Removal of free oxygen radicals, generated during reperfusion of an ischemic 
      organ by scavengers protects the tissue from reperfusion injury. The calcium 
      channel blocker verapamil is an effective cytoprotective agent, preventing 
      against reperfusion injury. The effects of verapamil were investigated previously 
      using hepatic, renal or cardiac ischemia-reperfusion injury models. We 
      investigated the effects of intravenous and intraportal administration of 
      verapamil in prevention from the injury caused by free oxygen radicals generated 
      during hepatic ischemia-reperfusion in rats. Thirty six male Sprague-Dawley rats 
      after laparotomy were subjected to hepatic ischemia for 30 and 45 min followed by 
      60 min of reperfusion. Two minutes before ischemia the rats were pretreated by 
      intravenous or intraportal administration of verapamil. The levels of glutathione 
      and thiobarbituric acid reacting substances (TBARs) referred to as 
      malonyldialdehyde (MDA) and the serum levels of transaminases were measured in 
      liver tissue 1 and 24 h after the onset of reperfusion. Statistical analysis of 
      the data by Student's t-test showed statistically significant differences between 
      the group pretreated intraportally with verapamil and the other groups. Verapamil 
      given intraportally exerted more beneficial effect. Therefore, we conclude that 
      intraportal verapamil administration reduces the ischemia-reperfusion injury 
      caused by free oxygen radicals.
FAU - Erdogan, O
AU  - Erdogan O
AD  - Department of General Surgery, Akdeniz University School of Medicine, Antalya, 
      Turkey. okaner7@yahoo.com
FAU - Yildiz, S
AU  - Yildiz S
FAU - Basaran, A
AU  - Basaran A
FAU - Demirbas, A
AU  - Demirbas A
FAU - Yesilkaya, A
AU  - Yesilkaya A
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Pol J Pharmacol
JT  - Polish journal of pharmacology
JID - 9313882
RN  - 0 (Calcium Channel Blockers)
RN  - CJ0O37KU29 (Verapamil)
SB  - IM
MH  - Animals
MH  - Calcium Channel Blockers/*administration & dosage
MH  - Infusions, Intravenous
MH  - Liver/*drug effects/enzymology/pathology
MH  - Male
MH  - Portal Vein/drug effects/enzymology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reperfusion Injury/*drug therapy/enzymology
MH  - Verapamil/*administration & dosage
EDAT- 2002/01/15 10:00
MHDA- 2002/07/02 10:01
CRDT- 2002/01/15 10:00
PHST- 2002/01/15 10:00 [pubmed]
PHST- 2002/07/02 10:01 [medline]
PHST- 2002/01/15 10:00 [entrez]
PST - ppublish
SO  - Pol J Pharmacol. 2001 Mar-Apr;53(2):137-41.