PMID- 11789087
OWN - NLM
STAT- MEDLINE
DCOM- 20020326
LR  - 20041117
IS  - 0024-7758 (Print)
IS  - 0024-7758 (Linking)
VI  - 46
IP  - 12
DP  - 2001 Dec
TI  - Interphase FISH--assisted second-trimester termination of a trisomy 21 fetus in 
      an IVF-ET twin pregnancy. A case report.
PG  - 1063-6
AB  - BACKGROUND: When confronting a dizygotic pregnancy with one fetus affected with 
      chromosomal aberrations, most couples would opt for selective termination of the 
      affected twin. CASE: Routine genetic amniocentesis was performed for an in vitro 
      fertilization-embryo transfer twin pregnancy at 18 weeks' gestation due to 
      advanced maternal age. After two weeks, cytogenetic analysis revealed that both 
      twins were male and one was affected with trisomy 21. At that time, ultrasound 
      examination could not tell them apart with certainty. With the aid of interphase 
      fluorescence in situ hybridization (FISH), we had no trouble locating the 
      affected twin and performed feticide successfully with an intracardiac potassium 
      chloride injection. At 37 weeks of gestation, a normal male was delivered along 
      with a macerated trisomy 21 fetus. CONCLUSION: In a dizygotic twin pregnancy 
      discordant for chromosome aberrations, when ultrasound cannot distinguish the 
      affected twin, performing interphase FISH with an appropriate chromosome probe 
      proves very useful in quickly and accurately locating the chromosomally abnormal 
      twin for selective termination.
FAU - Chang, S D
AU  - Chang SD
AD  - Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Lin-Kou 
      Medical Center, Tao-Yuan, Taiwan.
FAU - Chao, A S
AU  - Chao AS
FAU - Lai, Y M
AU  - Lai YM
FAU - Liu, H Y
AU  - Liu HY
FAU - Soong, Y K
AU  - Soong YK
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Reprod Med
JT  - The Journal of reproductive medicine
JID - 0173343
SB  - IM
MH  - Adult
MH  - Diagnosis, Differential
MH  - Down Syndrome/*genetics
MH  - Female
MH  - Fertilization in Vitro
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Infant, Newborn
MH  - Interphase
MH  - Male
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - *Pregnancy Reduction, Multifetal
MH  - Pregnancy Trimester, Second
MH  - Twins, Dizygotic/*genetics
EDAT- 2002/01/16 10:00
MHDA- 2002/03/27 10:01
CRDT- 2002/01/16 10:00
PHST- 2002/01/16 10:00 [pubmed]
PHST- 2002/03/27 10:01 [medline]
PHST- 2002/01/16 10:00 [entrez]
PST - ppublish
SO  - J Reprod Med. 2001 Dec;46(12):1063-6.