PMID- 11789196
OWN - NLM
STAT- MEDLINE
DCOM- 20020326
LR  - 20161018
IS  - 1003-5370 (Print)
IS  - 1003-5370 (Linking)
VI  - 20
IP  - 8
DP  - 2000 Aug
TI  - [Effects of shuanglong pill on mRNA expression of platelet-derived growth factor 
      A and monocyte chemoattractant protein-1 mRNA].
PG  - 612-5
AB  - OBJECTIVE: To explore the molecular mechanism of Shuanglong Pill (SLP) in 
      intervening atherosclerosis, mainly the effect of SLP on the mRNA expression of 
      the platelet-derived growth factor-A (PDGF-A) and the monocyte chemoattractant 
      protein-1 (MCP-1). METHODS: Using the hyperlipoprotein serum (HLS) of cultured 
      rabbits' aortic smooth muscle cell (SMC) to build the atherosclerotic cell model, 
      and medicated serum acting on the cell model by serum pharmacologic method. The 
      effect of SLP medicated serum on the level of PDGF-A, MCP-1 mRNA expression were 
      observed and analysed by means of reverse transcriptase-polymerase chain reaction 
      assay. RESULTS: It was found that HLS stimulated mRNA expression of the PDGF-A 
      and the MCP-1, but the medicated serum of SLP lowered their expression level. 
      CONCLUSION: SLP could inhibit the function of cellular auto-secreting growth 
      factor, it is one of the possible pharmacologic mechanism in intervening 
      atherosclerosis.
FAU - Wang, H
AU  - Wang H
AD  - Shanghai University of Traditional Chinese Medicine, Shanghai (200032).
FAU - Hu, W
AU  - Hu W
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Zhong Xi Yi Jie He Za Zhi
JT  - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese 
      journal of integrated traditional and Western medicine
JID - 9211576
RN  - 0 (Chemokine CCL2)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Platelet-Derived Growth Factor)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Arteriosclerosis/*metabolism/pathology
MH  - Cells, Cultured
MH  - Chemokine CCL2/*biosynthesis/genetics
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Female
MH  - Hyperlipidemias/metabolism/pathology
MH  - Male
MH  - Muscle, Smooth, Vascular/cytology/*metabolism
MH  - Platelet-Derived Growth Factor/*biosynthesis/genetics
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Rabbits
MH  - Random Allocation
EDAT- 2002/01/16 10:00
MHDA- 2002/03/27 10:01
CRDT- 2002/01/16 10:00
PHST- 2002/01/16 10:00 [pubmed]
PHST- 2002/03/27 10:01 [medline]
PHST- 2002/01/16 10:00 [entrez]
PST - ppublish
SO  - Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000 Aug;20(8):612-5.