PMID- 11790348
OWN - NLM
STAT- MEDLINE
DCOM- 20020301
LR  - 20191105
IS  - 1532-0456 (Print)
IS  - 1532-0456 (Linking)
VI  - 125
IP  - 3
DP  - 2000 Mar
TI  - Effects of aflatoxin B(1) on the liver and kidney of broiler chickens during 
      development.
PG  - 265-72
AB  - Aflatoxin B(1) (AFB(1)) negatively affects chicken (Gallus domesticus) growth. 
      This effect is more severe during development. We studied the influence of age on 
      the toxic effects of AFB(1) on plasma, renal and hepatic enzymes, under two 
      protocols, in adult and in developing Arbor-Acres chickens. Protocol A: 100 male 
      4-week-old chickens (640 g), received AFB(1), 0.5, 1.0, or 2.0 microg/g of feed 
      (daily p.o.), a fourth group received an aflatoxin-free diet. Five birds/group 
      were slaughtered at 7, 14, 21 and 28 days of treatment. Body, hepatic and renal 
      weights, succinate-dehydrogenase (SDH) and glutamate-dehydrogenase (GluDH) in 
      plasma and liver were measured. Hepatic SDH and GluDH decreased (P<0.05). 
      Protocol B: two groups of 24 male 1-week-old chickens (106 g) received either 
      aflatoxin-free feed (n=24) or AFB(1) feed (2.0 microg/g). At days 7, 14, 21 and 
      28, the same parameters of Protocol A were measured. AFB(1) markedly reduced body 
      weight gain (20-30%), plasma proteins, albumin, renal and hepatic protein content 
      (P<0.05) and increased absolute and relative weights of the kidney (P<0.05). SDH 
      and GluDH were reduced (P<0.05), while total renal gamma-glutamyltranspeptidase 
      (GGT) increased (P<0.05). Results suggest that serum proteins, SDH and GluDH are 
      sensitive early indicators of this toxicity that was more severe in developing 
      chickens. Decrease in serum albumin might be used as an early and suitable 
      indicator of the deleterious effect of this mycotoxin in developing chickens.
FAU - Quezada, T
AU  - Quezada T
AD  - Centro de Ciencias Agropecuarias, Universidad Autonoma de Aguascalientes, Mexico, 
      Mexico.
FAU - Cuellar, H
AU  - Cuellar H
FAU - Jaramillo-Juarez, F
AU  - Jaramillo-Juarez F
FAU - Valdivia, A G
AU  - Valdivia AG
FAU - Reyes, J L
AU  - Reyes JL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Comp Biochem Physiol C Toxicol Pharmacol
JT  - Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
JID - 100959500
RN  - 0 (Blood Proteins)
RN  - 0 (Serum Albumin)
RN  - 9N2N2Y55MH (Aflatoxin B1)
RN  - EC 1.3.99.1 (Succinate Dehydrogenase)
RN  - EC 1.4.1.2 (Glutamate Dehydrogenase)
RN  - EC 2.3.2.13 (Transglutaminases)
SB  - IM
MH  - Aflatoxin B1/administration & dosage/*toxicity
MH  - Animals
MH  - Blood Proteins/drug effects
MH  - Body Weight/drug effects
MH  - Chickens/growth & development
MH  - Drug Administration Schedule
MH  - Glutamate Dehydrogenase/metabolism
MH  - Kidney/*drug effects/pathology/physiopathology
MH  - Liver/*drug effects/pathology/physiopathology
MH  - Male
MH  - Organ Size/drug effects
MH  - Serum Albumin/drug effects
MH  - Succinate Dehydrogenase/metabolism
MH  - Transglutaminases/metabolism
EDAT- 2002/01/16 10:00
MHDA- 2002/03/02 10:01
CRDT- 2002/01/16 10:00
PHST- 2002/01/16 10:00 [pubmed]
PHST- 2002/03/02 10:01 [medline]
PHST- 2002/01/16 10:00 [entrez]
AID - S0742841399001073 [pii]
AID - 10.1016/s0742-8413(99)00107-3 [doi]
PST - ppublish
SO  - Comp Biochem Physiol C Toxicol Pharmacol. 2000 Mar;125(3):265-72. doi: 
      10.1016/s0742-8413(99)00107-3.