PMID- 11790459
OWN - NLM
STAT- MEDLINE
DCOM- 20020305
LR  - 20220310
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 176
IP  - 1
DP  - 2002 Feb 8
TI  - Immunohistochemical analysis of IQGAP1 expression in human colorectal carcinomas: 
      its overexpression in carcinomas and association with invasion fronts.
PG  - 101-9
AB  - In histopathological sections, it is frequently observed that carcinoma cells 
      move in and invade the stroma as coherent cell nests, rather than single cells. 
      We have called this type of movement 'cohort migration (CM)' and developed an in 
      vitro model, in which human colon adenocarcinoma cells move as coherent cell 
      sheets when stimulated with naturally occurring motogenic factor, hepatocyte 
      growth factor/scatter factor (HGF/SF). In this CM model, localized release from 
      cell-cell adhesion is essential for cell movement. Recently, we have shown that 
      IQGAP1, a target molecule of Cdc42 and Rac1 small GTPases, is involved in this 
      localized release from the E-cadherin-based cell-cell adhesion during CM. In this 
      study, we examined expression of IQGAP1 immunohistochemically in human colorectal 
      tissues and found that IQGAP1 was overexpressed in carcinoma tissues compared 
      with normal counterparts. Within the carcinoma tissue, IQGAP1 tended to be 
      expressed more at the invasion front than at the upper portions, and higher 
      levels of expression were observed in deeper two-thirds of carcinoma tissues than 
      in the superficial one-third. This expression pattern showing stronger signals in 
      deeper portions was most apparent in advanced carcinomas that invaded into the 
      subserosa. These findings supported a role of IQGAP1 in colon carcinoma invasion.
FAU - Nabeshima, Kazuki
AU  - Nabeshima K
AD  - Department of Pathology, Miyazaki Medical College Hospital, 5200 Kihara, 
      Kiyotake, Miyazaki 889-1692, Japan. kaznabes@post.miyazaki-med.ac.jp
FAU - Shimao, Yoshiya
AU  - Shimao Y
FAU - Inoue, Teruhiko
AU  - Inoue T
FAU - Koono, Masashi
AU  - Koono M
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (Cadherins)
RN  - 0 (Carrier Proteins)
RN  - 0 (IQ motif containing GTPase activating protein 1)
RN  - 0 (ras GTPase-Activating Proteins)
SB  - IM
MH  - Adenocarcinoma/metabolism
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cadherins/metabolism
MH  - Carcinoma/*metabolism
MH  - Carrier Proteins/*biosynthesis
MH  - Cell Adhesion
MH  - Cell Movement
MH  - Colon/metabolism
MH  - Colorectal Neoplasms/*metabolism
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Tumor Cells, Cultured
MH  - *ras GTPase-Activating Proteins
EDAT- 2002/01/16 10:00
MHDA- 2002/03/07 10:01
CRDT- 2002/01/16 10:00
PHST- 2002/01/16 10:00 [pubmed]
PHST- 2002/03/07 10:01 [medline]
PHST- 2002/01/16 10:00 [entrez]
AID - S030438350100742X [pii]
AID - 10.1016/s0304-3835(01)00742-x [doi]
PST - ppublish
SO  - Cancer Lett. 2002 Feb 8;176(1):101-9. doi: 10.1016/s0304-3835(01)00742-x.