PMID- 11790727
OWN - NLM
STAT- MEDLINE
DCOM- 20020319
LR  - 20220224
IS  - 1530-6860 (Electronic)
IS  - 0892-6638 (Linking)
VI  - 16
IP  - 3
DP  - 2002 Mar
TI  - Microarrayed allergen molecules: diagnostic gatekeepers for allergy treatment.
PG  - 414-6
AB  - Type I allergy is an immunoglobulin E (IgE)-mediated hypersensitivity disease 
      affecting more than 25% of the population. Currently, diagnosis of allergy is 
      performed by provocation testing and IgE serology using allergen extracts. This 
      process defines allergen-containing sources but cannot identify the 
      disease-eliciting allergenic molecules. We have applied microarray technology to 
      develop a miniaturized allergy test containing 94 purified allergen molecules 
      that represent the most common allergen sources. The allergen microarray allows 
      the determination and monitoring of allergic patients' IgE reactivity profiles to 
      large numbers of disease-causing allergens by using single measurements and 
      minute amounts of serum. This method may change established practice in allergy 
      diagnosis, prevention, and therapy. In addition, microarrayed antigens may be 
      applied to the diagnosis of autoimmune and infectious diseases.
FAU - Hiller, Reinhard
AU  - Hiller R
AD  - VBC-GENOMICS, A-1030 Vienna, Austria.
FAU - Laffer, Sylvia
AU  - Laffer S
FAU - Harwanegg, Christian
AU  - Harwanegg C
FAU - Huber, Martin
AU  - Huber M
FAU - Schmidt, Wolfgang M
AU  - Schmidt WM
FAU - Twardosz, Anna
AU  - Twardosz A
FAU - Barletta, Bianca
AU  - Barletta B
FAU - Becker, Wolf M
AU  - Becker WM
FAU - Blaser, Kurt
AU  - Blaser K
FAU - Breiteneder, Heimo
AU  - Breiteneder H
FAU - Chapman, Martin
AU  - Chapman M
FAU - Crameri, Reto
AU  - Crameri R
FAU - Duchene, Michael
AU  - Duchene M
FAU - Ferreira, Fatima
AU  - Ferreira F
FAU - Fiebig, Helmut
AU  - Fiebig H
FAU - Hoffmann-Sommergruber, Karin
AU  - Hoffmann-Sommergruber K
FAU - King, Te Piao
AU  - King TP
FAU - Kleber-Janke, Tamara
AU  - Kleber-Janke T
FAU - Kurup, Viswanath P
AU  - Kurup VP
FAU - Lehrer, Samuel B
AU  - Lehrer SB
FAU - Lidholm, Jonas
AU  - Lidholm J
FAU - Muller, Ulrich
AU  - Muller U
FAU - Pini, Carlo
AU  - Pini C
FAU - Reese, Gerald
AU  - Reese G
FAU - Scheiner, Otto
AU  - Scheiner O
FAU - Scheynius, Annika
AU  - Scheynius A
FAU - Shen, Horng-Der
AU  - Shen HD
FAU - Spitzauer, Susanne
AU  - Spitzauer S
FAU - Suck, Roland
AU  - Suck R
FAU - Swoboda, Ines
AU  - Swoboda I
FAU - Thomas, Wayne
AU  - Thomas W
FAU - Tinghino, Raffaela
AU  - Tinghino R
FAU - Van Hage-Hamsten, Marianne
AU  - Van Hage-Hamsten M
FAU - Virtanen, Tuomas
AU  - Virtanen T
FAU - Kraft, Dietrich
AU  - Kraft D
FAU - Muller, Manfred W
AU  - Muller MW
FAU - Valenta, Rudolf
AU  - Valenta R
LA  - eng
PT  - Journal Article
DEP - 20020114
PL  - United States
TA  - FASEB J
JT  - FASEB journal : official publication of the Federation of American Societies for 
      Experimental Biology
JID - 8804484
RN  - 0 (Allergens)
RN  - 0 (Recombinant Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/genetics/*immunology/isolation & purification
MH  - Humans
MH  - Hypersensitivity, Immediate/*diagnosis/immunology/therapy
MH  - Immunoglobulin E/immunology
MH  - Oligonucleotide Array Sequence Analysis/*methods
MH  - Recombinant Proteins/immunology/isolation & purification
EDAT- 2002/01/16 10:00
MHDA- 2002/03/20 10:01
CRDT- 2002/01/16 10:00
PHST- 2002/01/16 10:00 [pubmed]
PHST- 2002/03/20 10:01 [medline]
PHST- 2002/01/16 10:00 [entrez]
AID - 01-0711fje [pii]
AID - 10.1096/fj.01-0711fje [doi]
PST - ppublish
SO  - FASEB J. 2002 Mar;16(3):414-6. doi: 10.1096/fj.01-0711fje. Epub 2002 Jan 14.