PMID- 11793389
OWN - NLM
STAT- MEDLINE
DCOM- 20020423
LR  - 20190901
IS  - 0146-6615 (Print)
IS  - 0146-6615 (Linking)
VI  - 66
IP  - 3
DP  - 2002 Mar
TI  - Genetic variations of human herpesvirus 7 by analysis of glycoproteins B and H, 
      and R2-repeat regions.
PG  - 370-7
AB  - Clinical isolates of human herpesvirus 7 (HHV-7) from the saliva of healthy 
      individual were investigated for genetic variations in the regions of two 
      immediate-early (IE) genes, the glycoprotein B (gB) and glycoprotein H (gH) 
      genes, and in R2-repeat. The genomic DNA of 24 isolates from citizens of 
      Thailand, Japan, and the United States was amplified to detect size variations in 
      the IE-1 and IE-2 loci, but none was observed, suggesting that there was no 
      deletion or insertion in these genes, in contrast with an IE gene of human 
      herpesvirus 6 (HHV-6). The sequences of the gB gene from isolates acquired from 5 
      Japanese and 8 Thai subject were then compared with those of American strains JI 
      and RK with respect to codons that are known to differentiate gB alleles. All the 
      isolates were found to have gB allele C except for the JI strain, which has 
      allele F. Variability was also observed in five specific gH codons, resulting in 
      6 different groups. The HHV-7 isolates might be classified into two major genetic 
      variants by combining their gB and gH allelic groupings. In the present study, 
      only JI belonged to variant 1, while the rest of the isolates appeared to belong 
      to variant 2. In the R2-repeat region, size heterogeneities were observed among 
      the 24 isolates, due to different repeat numbers (17, 15, 14, 13, or 12 repeats). 
      Therefore, we used the R2-repeat to identify the origins of isolates in a study 
      of HHV-7 transmission, and found HHV-7 to be transmitted within a family from 
      both mothers and fathers to their children.
CI  - Copyright 2002 Wiley-Liss, Inc.
FAU - Thawaranantha, Duanthanorm
AU  - Thawaranantha D
AD  - Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand.
FAU - Chimabutra, Kanittha
AU  - Chimabutra K
FAU - Balachandra, Kruavon
AU  - Balachandra K
FAU - Warachit, Paijit
AU  - Warachit P
FAU - Pantuwatana, Somsak
AU  - Pantuwatana S
FAU - Tanaka-Taya, Keiko
AU  - Tanaka-Taya K
FAU - Inagi, Reiko
AU  - Inagi R
FAU - Kurata, Takeshi
AU  - Kurata T
FAU - Yamanishi, Koichi
AU  - Yamanishi K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (Codon)
RN  - 0 (Immediate-Early Proteins)
RN  - 0 (Viral Envelope Proteins)
RN  - 0 (glycoprotein B, human herpesvirus 7)
RN  - 0 (glycoprotein H, herpesvirus 7)
SB  - IM
MH  - Adult
MH  - Cell Line
MH  - Child
MH  - Codon
MH  - Female
MH  - *Genes, Viral
MH  - Genetic Heterogeneity
MH  - *Genetic Variation
MH  - Herpesvirus 7, Human/*genetics/isolation & purification
MH  - Humans
MH  - Immediate-Early Proteins/genetics
MH  - Infectious Disease Transmission, Vertical
MH  - Leukocytes, Mononuclear/cytology
MH  - Male
MH  - Roseolovirus Infections/pathology/transmission/*virology
MH  - *Terminal Repeat Sequences
MH  - Viral Envelope Proteins/*genetics
EDAT- 2002/01/17 10:00
MHDA- 2002/04/24 10:01
CRDT- 2002/01/17 10:00
PHST- 2002/01/17 10:00 [pubmed]
PHST- 2002/04/24 10:01 [medline]
PHST- 2002/01/17 10:00 [entrez]
AID - 10.1002/jmv.2154 [pii]
AID - 10.1002/jmv.2154 [doi]
PST - ppublish
SO  - J Med Virol. 2002 Mar;66(3):370-7. doi: 10.1002/jmv.2154.