PMID- 11793794
OWN - NLM
STAT- MEDLINE
DCOM- 20020415
LR  - 20191105
IS  - 0741-0395 (Print)
IS  - 0741-0395 (Linking)
VI  - 21 Suppl 1
DP  - 2001
TI  - Assessing linkage of immunoglobulin E using a meta-analysis approach.
PG  - S97-102
AB  - We report results using a new meta-analysis procedure to assess linkage of 
      immunoglobulin E (IgE), an asthma related quantitative trait, using the nine data 
      sets provided by the Genetic Analysis Workshop 12. This meta-analysis procedure 
      combines univariate Haseman-Elston statistics across studies gaining strength by 
      collating possibly distinct marker maps. We performed univariate Haseman-Elston 
      over all data sets and identified linkage (p < 0.05) to some marker in at least 
      one study on virtually every chromosome. Using the proposed meta-analysis 
      procedure, we detected suggestive linkage (p-value < 7.4 x 10(-4), [Lander and 
      Kruglyak, Nat Genet 11:214-47, 1995]) for two regions on chromosome 4 (around 50 
      and 150 cM) and one region on chromosome 11 (around 125 cM). We also identified 
      areas which were evocative (p-value < 0.02) for linkage: chr 5-40 cM, chr 7-98 
      cM, chr 9-65 cM, chr 13-110 cM, chr 16-10 cM and approximately 105 cM, chr 17-70 
      cM, and chr 20-25 cM.
FAU - Etzel, C J
AU  - Etzel CJ
AD  - Department of Epidemiology, UT MD Anderson Cancer Center, Box 189, 1515 Holcombe 
      Blvd., Houston, TX 77030, USA.
FAU - Costello, T J
AU  - Costello TJ
LA  - eng
GR  - ES09912/ES/NIEHS NIH HHS/United States
GR  - HG02275/HG/NHGRI NIH HHS/United States
GR  - R25 CA57730/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genet Epidemiol
JT  - Genetic epidemiology
JID - 8411723
RN  - 0 (Genetic Markers)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Asthma/epidemiology/*genetics/immunology
MH  - Child
MH  - Chromosome Mapping/*statistics & numerical data
MH  - Chromosomes, Human, Pair 11
MH  - Chromosomes, Human, Pair 4
MH  - Chromosomes, Human, Pair 5
MH  - Female
MH  - Genetic Markers/genetics
MH  - Humans
MH  - Immunoglobulin E/blood/*genetics
MH  - Male
MH  - *Quantitative Trait, Heritable
EDAT- 2002/01/17 10:00
MHDA- 2002/04/16 10:01
CRDT- 2002/01/17 10:00
PHST- 2002/01/17 10:00 [pubmed]
PHST- 2002/04/16 10:01 [medline]
PHST- 2002/01/17 10:00 [entrez]
AID - 10.1002/gepi.2001.21.s1.s97 [doi]
PST - ppublish
SO  - Genet Epidemiol. 2001;21 Suppl 1:S97-102. doi: 10.1002/gepi.2001.21.s1.s97.