PMID- 11795520
OWN - NLM
STAT- MEDLINE
DCOM- 20020222
LR  - 20190616
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 928
DP  - 2001 Apr
TI  - Caloric restriction in primates.
PG  - 287-95
AB  - Caloric restriction (CR) remains the only nongenetic intervention that 
      reproducibly extends mean and maximal life span in short-lived mammalian species. 
      This nutritional intervention also delays the onset, or slows the progression, of 
      many age-related disease processes. The diverse effects of CR have been 
      demonstrated many hundreds of times in laboratory rodents and other short-lived 
      species, such as rotifers, water fleas, fish, spiders, and hamsters. Until 
      recently, the effects of CR in longer-lived species, more closely related to 
      humans, remained unknown. Long-term studies of aging in nonhuman primates 
      undergoing CR have been underway at the National Institute on Aging (NIA) and the 
      University of Wisconsin-Madison (UW) for over a decade. A number of reports from 
      the NIA and UW colonies have shown that monkeys on CR exhibit nearly identical 
      physiological responses as reported in laboratory rodents. Studies of various 
      markers related to age-related diseases suggest that CR will prevent or delay the 
      onset of cardiovascular disease, diabetes, and perhaps cancer, and preliminary 
      data indicate that mortality due to these and other age-associated diseases may 
      also be reduced in monkeys on CR, compared to controls. Conclusive evidence 
      showing that CR extends life span in primates is not presently available; 
      however, the emerging data from the ongoing primate studies strengthens the 
      possibility that the diverse beneficial effects of CR on aging in rodents will 
      also apply to nonhuman primates and perhaps ultimately to humans.
FAU - Lane, M A
AU  - Lane MA
AD  - Laboratory of Neurosciences, Gerontology Research Center, National Institute on 
      Aging, National Institutes of Health, Baltimore, Maryland 21224, USA. 
      MLANE@vms.grc.nia.nih.gov
FAU - Black, A
AU  - Black A
FAU - Handy, A
AU  - Handy A
FAU - Tilmont, E M
AU  - Tilmont EM
FAU - Ingram, D K
AU  - Ingram DK
FAU - Roth, G S
AU  - Roth GS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Biomarkers)
RN  - 57B09Q7FJR (Dehydroepiandrosterone Sulfate)
SB  - IM
MH  - Aging/*metabolism
MH  - Animals
MH  - Biomarkers
MH  - Body Composition
MH  - Body Weight
MH  - Cardiovascular Diseases/prevention & control
MH  - Cellular Senescence
MH  - Dehydroepiandrosterone Sulfate/blood
MH  - Diabetes Mellitus/prevention & control
MH  - *Energy Intake
MH  - Energy Metabolism
MH  - Female
MH  - *Food Deprivation
MH  - *Longevity
MH  - Macaca mulatta
MH  - Male
MH  - Mammals/physiology
MH  - Models, Animal
MH  - Neoplasms, Experimental/prevention & control
MH  - Osteoporosis/prevention & control
MH  - Primates
MH  - Species Specificity
RF  - 25
EDAT- 2002/01/25 10:00
MHDA- 2002/02/23 10:01
CRDT- 2002/01/25 10:00
PHST- 2002/01/25 10:00 [pubmed]
PHST- 2002/02/23 10:01 [medline]
PHST- 2002/01/25 10:00 [entrez]
AID - 10.1111/j.1749-6632.2001.tb05658.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2001 Apr;928:287-95. doi: 10.1111/j.1749-6632.2001.tb05658.x.