PMID- 11796192
OWN - NLM
STAT- MEDLINE
DCOM- 20020321
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 318
IP  - 2
DP  - 2002 Jan 25
TI  - Effect of electroacupuncture on the stress-induced changes in brain-derived 
      neurotrophic factor expression in rat hippocampus.
PG  - 85-8
AB  - Stress induces neuronal atrophy and death especially in the hippocampus. 
      Alterations in the expression of neurotrophic factors are implicated in 
      stress-induced hippocampal degeneration. In the hippocampus, stress decreases 
      brain-derived neurotrophic factor (BDNF) mRNA levels. In oriental medicine, 
      acupuncture has long been employed as a treatment of numerous disorders. The 
      objective of this study was to examine whether electroacupuncture (EA) 
      stimulation can influence BDNF expression in the hippocampus of rats exposed to 
      immobilization stress. Rats were immobilized in plastic bags, and then subjected 
      to EA at ST36 Zusanli. After treatment, the animals were decapitated and the 
      hippocampi were rapidly removed and processed for RNA isolation and reverse 
      transcription. Real-time polymerase chain reaction analysis showed that EA 
      stimulation significantly restored BDNF mRNA expression declined by 
      immobilization stress. The results suggest that EA may relieve neuropathological 
      effects of stress by modulating neurotrophic factor expression.
FAU - Yun, Su-Jin
AU  - Yun SJ
AD  - Graduate School of East-West Medical Science, Kyung Hee University, 1 Seochun, 
      Yong-In 449-701, South Korea.
FAU - Park, Hi-Joon
AU  - Park HJ
FAU - Yeom, Mi-Jung
AU  - Yeom MJ
FAU - Hahm, Dae-Hyun
AU  - Hahm DH
FAU - Lee, Hye-Jung
AU  - Lee HJ
FAU - Lee, Eunjoo H
AU  - Lee EH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Down-Regulation/*physiology
MH  - *Electroacupuncture
MH  - Hippocampus/*metabolism/physiopathology
MH  - Male
MH  - Nerve Degeneration/metabolism/physiopathology/*prevention & control
MH  - Neurons/*metabolism
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Restraint, Physical
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Stress, Physiological/metabolism/physiopathology/*therapy
MH  - Up-Regulation/*physiology
EDAT- 2002/02/14 10:00
MHDA- 2002/03/22 10:01
CRDT- 2002/02/14 10:00
PHST- 2002/02/14 10:00 [pubmed]
PHST- 2002/03/22 10:01 [medline]
PHST- 2002/02/14 10:00 [entrez]
AID - S0304394001024922 [pii]
AID - 10.1016/s0304-3940(01)02492-2 [doi]
PST - ppublish
SO  - Neurosci Lett. 2002 Jan 25;318(2):85-8. doi: 10.1016/s0304-3940(01)02492-2.